Fosfomycin
- Atc Codes:J01XX01
- CAS Codes:78964-85-9
- PHARMGKB ID:78964-85-9
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Unlabeled Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Belgium: Monuril; France: Fosfocine, Monuril, Uridoz; Germany: Infectofos, Monuril; Greece: Monurol; Hungary: Monural; Ireland: Monuril; Italy: Berny AD, Fosfocin, Fosfomicina, Monuril; Luxembourg: Monuril; Netherlands: Monuril; Poland: Monural; Portugal: Fosfomicina, Monuril; Romania: Monural; Slovakia: Monural; Spain: Fosfocina, Monurol, Solufos.
North America
Canada: Monurol; USA: Monurol.
Latin America
Argentina: Veramina; Brazil: Monuril; Mexico: Fosfocil.
Asia
Japan: Bluebacirin, Clulolaxin, FOM, Foscacilin, Fosfomin, Fosfomycin, Foskoricin, Fosmalin, Fosmicin, Fosmy, Frazemicin, Harosmin, Hoskarize, Isoramycin.
Drug combinations
Chemistry
Fosfomycin Tromethamine: C~3~H~7~O~4~P C~4~H~11~NO~3~. Mw: 259.19. (1) Phosphonic acid, (3-methyloxiranyl)-, (2R-cis)-, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1); (2)(1R,2S)-(1,2-Epoxypropyl)phosphonic acid, compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1). CAS-78964-85-9 (1991).
Pharmacologic Category
Urinary Anti-infectives. (ATC-Code: J01XX01).
Mechanism of action
As a phosphoric acid derivative, fosfomycin inhibits bacterial wall synthesis (bactericidal) by inactivating the enzyme pyruvyl transferase, critical in synthesis of cell walls by bacteria. Tromethamine salt is preferable to calcium salt due to its superior absorption.
Therapeutic use
Single oral dose in treatment of uncomplicated urinary tract infections in women due to susceptible strains of E. coli and Enterococcus.
Pregnancy and lactiation implications
There are no adequate, well-controlled studies in pregnant women. Use not recommended during lactation.
Unlabeled use
Multiple doses investigated for complicated urinary tract infections in men.
Contraindications
Hypersensitivity to fosfomycin or any component of the formulation.
Warnings and precautions
Prolonged use may result in fungal or bacterial superinfection, including C. difficile-associated diarrhea and pseudomembranous colitis.