Gallium Nitrate

Table of contents

  • Brand Names
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Toxicological Effects
  • Genes that may be involved
  • Drug Interactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names

North America

USA: Ganite.

Drug combinations


Gallium Nitrate: GaN~3~O~9~ 9H~2~O. Mw: 417.88. Nitric acid, gallium salt, nonahydrate. CAS-135886-70-3; CAS-13494-90-1 (anhydrous)(1992).

Pharmacologic Category

Bone Resorption Inhibitors; Calcium-Lowering Agent. (ATC-Code: V03AG).

Mechanism of action

Inhibits bone resorption by inhibiting osteoclast function. Gallium nitrate appears to be effective in parathyroid hormone-related protein (PTHrP) and non-PTHrP-associated hypercalcemia.

Therapeutic use

Used in conjunction with adequate hydration for management of symptomatic hypercalcemia associated with malignant neoplasms in patients whose hypercalcemia is not adequately managed with conventional methods of treatment (e.g. hydration alone).

Pregnancy and lactiation implications

Reproduction studies not conducted. Not recommended during lactation.

Unlabeled use


Hypersensitivity to gallium nitrate or any component of formulation. Severe renal dysfunction (serum creatinine >2.5 mg/dL).

Warnings and precautions

Hazardous agent. Hypocalcemia is possible. Transient hypophosphatemia may occur. May cause renal toxicity. Concurrent administration with other nephrotoxic drugs (e.g. aminoglycosides, amphotericin B) may increase risk for renal insufficiency. Use with caution in cardiovascular disease (heart failure or hypertension) and pulmonary disease. Discontinue gallium nitrate during treatment with nephrotoxic drugs.



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