Gliclazide
- Atc Codes:A10BB09
- CAS Codes:21187-98-4
- PHARMGKB ID:21187-98-4
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Substrate of
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Diamicron; Belgium: Diamicron, Gliclazide; Bulgaria: Diab, Diabrezide, Diaprel, Diglical, Normodiab; Cyprus: Diamicron, Glicazide, Medoclazide; Denmark: Diamicron, Glicazid; Estonia: Diabrezide, Diaprel, Glicada, Gliclazide, Glydium; France: Diamicron, Glicazide; Germany: Diamicron, Glibemat, Glicada, Glicazid, Glicazide; Greece: Diabezid, Diadeon, Diadistane, Diamicron, Gliclazide; Hungary: Diabrezide, Diaprel, Gliclada, Gluctam, Zicarux; Ireland: Diamicron; Italy: Diamicron; Luxembourg: Diamicron; Netherlands: Diamicron, Glicazide; Poland: Diabezidum, Diabrezide, Diaklat, Diaprel, Diazidan, Gliclazide, Gliclazyd, Glinormax, Gluctam, Norsulin; Portugal: Diamicron; Spain: Diamicron, Unidiamicron; Sweden: Diamicron; UK: Diamicron.
North America
Canada: Diamicron, Gliclazide.
Latin America
Argentina: Aglucide, Diamicron, Gliclazida, Unava; Brazil: Azucon, Diamicron, Erowgliz, Glicaron; Mexico: Diamicron.
Asia
Japan: Benelaxa, Crawnart, Diaglico, Glimicron, Glimiran, Glutameal, Kyowacron, Pharlinde, Ruimenia.
Drug combinations
Chemistry
Gliclazide: C~15~H~21~N~3~O~3~S. Mw: 323.41. 1-(3-Azabicyclo[3.3.0]oct-3-yl)-3-(p-tolylsulfonyl)urea. CAS-21187-98-4.
Pharmacologic Category
Antidiabetic Agents; Sulfonylureas. (ATC-Code: A10BB09).
Mechanism of action
Stimulates insulin release from pancreatic β-cells. Reduces glucose output from liver. Lowers plasma glucose concentrations. Has also been shown to decrease platelet aggregation at therapeutic doses.
Therapeutic use
Management of type 2 diabetes mellitus (non-insulin-dependent, NIDDM).
Pregnancy and lactiation implications
Crosses placenta. Insulin is the drug of choice for control of diabetes mellitus during pregnancy. Potential for neonatal hypoglycemia contraindicates use during lactation.
Unlabeled use
Contraindications
Hypersensitivity to gliclazide, sulfonylureas, or any component of the formulation. Type 1 diabetes mellitus (insulin-dependent, IDDM), diabetic ketoacidosis with or without coma. Renal or hepatic impairment. Pregnancy.
Warnings and precautions
Oral hypoglycemic drugs may be associated with an increased cardiovascular mortality. Hypoglycemia possible (use with caution). Sulfonamide allergy (use in sulfonamide allergy specifically contraindicated). Caution if patient is exposed to stress (fever, infection, surgery, trauma).