Influenza Virus Vaccine

Table of contents

  • Brand Names
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Genes that may be involved
  • Drug Interactions
  • Dosage
  • Special Considerations

Brand Names

Europe

Austria: Addigrip, Batrevac, Begrivac, Celvapan, Daronrix, Fluad, Fluvaccinol, Fluvirin, Focetria, Idflu, Intanza, Inflexal V, Influvac, Invivac, Optaflu, Pandemrix, Prä-pandemischer Influenza-Impfstoff (H5N1), Prepandrix, Sandovac, Vaxigrip; Belgium: α-Rix, Inflexal V, Influvac, Pandemrix, Vaxigrip; Bulgaria: Begrivac, Fluad, Fluarix, Flocetria, Idflu, Inflexal V, Influvac, Intanza, Optaflu, Pandemrix, Prepandemická Vakcína Proti Chřipce (H5N1), Prepandrix, Vaxigrip; Cyprus: Agrippal, Fluarix, Influvac, Vaxigrip; Denmark: Vaxigrip; Estonia: Celvapan, Daronrix, Fluarix, Flocetria, Idflu, Influvac, Intanza, Optaflu, Pandemic Influenza Vaccine H5N1, Pandemrix, Prepamdemic Influenza Vaccine H5N1, Prepandrix, Vaxigrip; Finland: Begrivac, Fluarix, Flupar-Vaccine, Inflexal V, Influvac, Pandemrix, Vaxigrip; France: Fluarix, Immugrip, Mutagrip, Previgrip, Tetagrip, Vaxigrip; Germany: Addigrip, Afluria, Begrivac, Celvapan, Daronrix, Fluad, Fluarix, Fluvaccinol, Focetria, Foclivia, Grippeimpfstoff, Idflu, InfectoVac Flu Inflexal V, Influsplit, Influvac, Intanza, Invivac, Mutagrip, Optaflu, Pandemrix, Prä-pandemischer Influenza-Impfstoff (H5N1), Prepandrix, Vacciflu; Hungary: Focetria; Ireland: Addiflu, Agrippal, Begrivac, Celvapan, Daronrix, Enzira, Fluad, Fluarix, Focetria, Foclivia, Idflu, Inflexal, Inactivated Influenza (Split Virion), Inactivated Influenza Vaccine (Split Viron) BP, Inflexal, Influvac, Invivac, Intanza, Optaflu, Pandemic Influenza Vaccine (H5N1), Pandemrix, Prepandemic, Prepandrix; Italy: Agrippal, Batrevac, Begrivac, Fluad, Fluarix, Focetria, Inflexal V, Influpozzi Adiuvato, Influvac, Isiflu V, Isigrip, Vaxigrip; Latvia: Fluarix, Focetria, Influvac, Optaflu, Vaxigrip; Lithuania: Fluarix, Focetria, Idflu, Influvac, Optaflu, Pandemic Influenza Vaccine H5N1, Pandemrix, Vaxigrip; Luxembourg: Focetria, Optaflu, Pandemrix, Prepamdemic Influenza Vaccine H5N1, Prepandrix; Malta: Focetria, Optaflu, Pandemrix, Prepamdemic Influenza Vaccine H5N1, Prepandrix; Netherlands: Fluarix, Fluvirin, Mutagrip, Vaxigrip; Poland: Agrippal, Begrivac, Celvapan, Daronrix, Fluarix, Fluvirin, Focetria, Idflu, Inflexal V, Influvac, Intanza, Isiflu, Optaflu, Pandemrix, Prepandemic, Prepandrix, Vaxigrip; Portugal: Addigrip, Batrevac, Celvapan, Chiroflu, Daronrix, Fluad, Fluarix, Fluvirin, Focetria, Idflu, Inflexal V, Influvac, Intanza, Invivac, Istivac, Optaflu, Pandermrix, Prepandemic Influenza Vaccinem, Prepandrix, Vaxigrip; Romania: Cantgrip, Celvapan, Daronrix, Fluarix, Focetria, Griplaval, Idflu, Inflexal V, Influvac, Intanza, Optaflu, Pandemrix, Prepandrix, Vaccin Gripal Pre-Pandemic, Vaccin Gripal Trivalent Purificat SI Inactivat, Vaxigrip; Slovakia: Begrivac, Celvapan, Daronrix, Fluarix, Focetria, Foclivia, Idflu, Influvac, Intanza Optaflu, Pandemic Influenza Vaccine H5N1, Pandemrix, Prepandemic Influenza Vaccine H5N1, Prepandrix, Vaxigrip; Slovenia: Fluarix, Focetria, Optaflu, Pandemrix; Spain: Chiroflu, Fluarix, Gripavac, Inflexal V, Influvac, Levrison, Mutagrip, Vacuna Antigripal, Vacuna Antigripal Polivalente; Sweden: Addigrip, Afluria, Agrippal, Batrevac, Begrivac, Celvapan, Daronrix, Fluad, Fluarix, Focetria, Idflu, Inflexal V, Influvac, Intanza, Invivac, Optaflu, Pandemic Influenza Vaccine H5N1, Pandemrix, Prepandemic Influenza vaccine (H5N1), Vaccin mot influensa SB (Mutagrip), Vaxigrip; UK: Agrippal, Begrivac, Enzira, Fluarix, Fluvirin, Imuvac, Inactivated Influenza Vaccine (Split Virion) BP, Inflexal V, Influenza Vaccine, Influvac, Intanza, Mastaflu, Optaflu, Pandemrix, Viroflu.

North America

Canada: Arepanrix H1N1, Influenza A (H1N1) 2009 Pandemic Monovalent Vaccine, Influvac, Vaxigrip; USA: Afluria, Agriflu, Fluarix, FluLaval, FluMist, Fluvirin, Fluzone, Influenza A (H1N1) 2009 Monovalent Vaccine, Influenza Virus Vaccine H5N1.

Latin America

Argentina: Agrippal, Begrivac, Fluarix, Influvax, Istivac, Nilgrip, Vaxigrip; Brazil: Agrippal, Vacina contra Gripe, Vacina de Vírus Inativado contra Gripe; Mexico: Fluarix, Fluzone.

Asia

Japan: Biken HA, Flu-Syringe, Influenza HA Vaccine, Influ «Kaketsuken» Syringe.

Drug combinations

Chemistry

Pharmacologic Category

Serums, Toxoids, and Vaccines; Vaccines. Inactivated Viral Vaccine. Live Viral Vaccine. (ATC-Code: J07BB).

Mechanism of action

Promotes immunity to influenza virus by inducing specific antibody production.

Therapeutic use

Provision of active immunity to influenza virus strains contained in vaccine.

Pregnancy and lactiation implications

It is suggested that pregnancy may increase risk of serious medical complications from influenza infection. Use of parenteral inactivated influenza vaccine (not intranasal live influenza vaccine) recommended in pregnant women.

Unlabeled use

Contraindications

Hypersensitivity to influenza virus vaccine, or any component of the formulation. Presence of acute respiratory disease or other active infections or febrile illnesses. Active neurological disorder. Children 2-17 years of age receiving aspirin therapy (nasal spray).

Warnings and precautions

Anaphylactoid or hypersensitivity reactions might occur. Use with caution in history of Guillain-Barré syndrome. Use with caution in severely immunocompromised patients (e.g. patients receiving chemo/radiation therapy or other immunosuppressive therapy). Some products may contain arginine, chicken egg protein, gelatin, or gentamicin, neomycin, polymyxin, or thimerosal. Children with severe anaphylactic reactions to eggs should generally not receive vaccine. Use with caution in history of bleeding disorders (including thrombocytopenia) and/or patients on anticoagulant therapy (risk of bleeding or hematoma from I.M. administration). Packaging might contain natural latex rubber. For intranasal use only. Nasal spray should be used cautiously in asthma or children under 5 years of age with recurrent wheezing (increased risk of wheezing following vaccination). Influenza vaccines from previous seasons must not be used. Allergic reactions (e.g. urticaria, angioedema, anaphylaxis, allergic asthma) may result (rarely). Immune response to vaccine and efficacy may be reduced in immunosuppressed patients. May not protect all vaccine recipients against influenza. Annual vaccination needed. Administration should be delayed in moderate to severe acute febrile illness until symptoms have subsided. Risk of hematoma from I.M. injections.

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