Hazardous agent. Causes bone marrow suppression, including potentially severe cytopenias, and very rarely, aplastic anemia (use caution in pre-existing myelosuppression and with concomitant medications which cause myelosuppression). Hemorrhagic cerebrovascular events observed. Commonly associated with fever and flu-like symptoms. May cause hepatotoxicity. Acute hypersensitivity reactions reported (rarely) with alpha interferons. Hypertriglyceridemia reported. May cause severe psychiatric adverse events (e.g. depression, psychosis, mania, suicidal behavior/ideation) in patients with and without previous psychiatric symptoms. Ocular effects occurred (or aggravated)(use caution in pre-existing eye disorders). Pulmonary effects (pulmonary infiltrates, pneumonitis and pneumonia) reported (use with caution in history of pulmonary disease). Do not treat patients with visceral AIDS-related Kaposi’s sarcoma associated with rapidly-progressing or life-threatening disease. Avoid use in history of autoimmune disorders (risk of development of autoimmune disorders). Worsening of psoriasis and sarcoidosis (and development of new sarcoidosis) reported. Use with caution in cardiovascular disease (ischemic or thromboembolic), arrhythmias, hypertension, and in history of MI or prior therapy with cardiotoxic drugs. May cause hypotension, arrhythmia, tachycardia, cardiomyopathy and/or MI. Avoid use in patients being treated for chronic hepatitis B or C with history of autoimmune disease or who are immunosuppressed transplant recipients. Use with caution in coagulation disorders. Diabetes reported (use caution in history of diabetes mellitus, particularly if prone to DKA). May cause or aggravate fatal or life-threatening infectious disorders. May cause or aggravate fatal or life-threatening ischemic disorders. Thyroid disorders (hyper-/hypothyroidism) reported (use with caution in pre-existing thyroid disease). Some formulations contain albumin.