Table of contents

  • Brand Names
  • Drug Combinations
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Unlabeled Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Toxicological Effects
  • Caution and personalized dose adjustment in patients with the following genotypes
  • Other genes that may be involved
  • Substrate of
  • Inhibits
  • Drug Interactions
  • Nutrition/Nutraceutical Interactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names


Austria: Fungoral, Ketoconazol, Nizoral; Belgium: Nizoral; Bulgaria: Ketoconazole, Ketozal, Nizoral; Cyprus: Ilgem, Ketozal, Ketrozol, Nizoral, Tinuvin, Vafluson; Czech Republic: Asquam, Nizoral; Denmark: Ketoconazole, Nizoral; Estonia: Altis, Ketoconazol, Mikanisal, Nizoral, Oronazol, Senosal; Finland: Ketoconazol, Konact, Nizoral; France: Ketoconazole, Ketoderm, Nizoral; Germany: Fungoral, Ketoconazol, Nizoral, Terzolin; Greece: Abba, Adenosan, Aquarius, Botaderm, Ebersept, Flidaphen, Fungoral, Ilgem, Ketoconazole, Libroman, Mycofebrin, Neo-Egmol, Nyoxep, Reprol, Sostatin; Hungary: Ketospor, Korfa, Nizoral; Ireland: Ketopine, Ketozol, Nizoral; Italy: Asquam, Ketoconazolo, Nizoral, Triatop; Latvia: Fungoral, Ketoconazol, Mikanisal, Nizoral; Lithuania: Altis, Ketoconazol, Nizoral; Luxembourg: Nizoral; Malta: Nizoral, Dermatin Shampoo; Netherlands: Asquam, Ketoconazol, Nizoral; Poland: Apo-Keto SR, Fungores, Ketokonazol, Nizoral, Noell, Zoxinat; Portugal: Cetoconazol, Farmorol, Nizale, Nizoral, Tedol; Romania: Kefungin, Keto-Tis, Ketoconazol, Ketostin, Nizoral; Slovakia: Nizoral; Slovenia: Oronazol; Spain: Fungarest, Fungo, Keto-cure, Ketoconazol, Ketoisdin, Medezol, Panfungol; Sweden: Fundan, Fungoral, Ketoconazol, Ketoson, Kezol; UK: Daktarin Gold, Daktarin Intensive, Ketoconazole, Nizoral.

North America

Canada: Ketoconazole, Ketoderm, Nizoral, Nu-Ketocon; USA: Extina, Ketoconazole, Ketozole, Nizoral, Xolegel.

Latin America

Argentina: Eumicel, Faction, Fangan, Fitonal, Grenfung, Keduo, Ketoconazol, Ketolef, Ketonazol, Micoral, Orifungal, Perative, Pitylis, Quadion, Sinamida Accion Caspa, Socosep, Tikl; Brazil: Aciderm-Cetoconazol, Arcolan, Candiderm, Candoral, Capel, Cetoconalab, Cetoconazol, Cetoderm, Cetomed, Cetomizol, Cetonax, Cetoneo, Cetonil, Cetonin, Dermitrat, Ketonazol, Lozan, Miconan, Micoral, Nizoral, Nizoretic, Noriderm, Noronal, Zanoc, Zolmicol; Mexico: Akorazol, Biozoral, Conazol, Cremosan, Ergomicon, Eurolat, Fungipar, Fungoral, Hispazzon, Honzil, Ketoconazol, Ketofar, Ketomed, Ketomizol, Ketoril, Konaderm, Konaturil, Lizovag, Messelzol, Micoser, MI-KE-SON’S-V, Mycocil, Mycodib, Nastil, Nazolfarm, Nazoltec, Nizoral, Onofin-K, Prenalon, Remecon, Strizole, Termizol, Tiniasil, Tiniazol, Toconal, Tolcrem, Tomiko, Triatop.


Japan: Ketopamin, Nitrazen, Nizoral, Pulna.

Drug combinations

Ketoconazole and Clindamycin

Ketoconazole and Cyproheptadine

Ketoconazole, Gentamicin, and Hydrocortisone

Ketoconazole, Dexamethasone, Gentamicin, and Hydrocortisone

Other Ketoconazole combinations: Dexpanthenol


Ketoconazole: C~26~H~28~Cl~2~N~4~O~4~. Mw: 531.43. (1) Piperazine, 1-acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-, cis-; (2)(±)-cis-1-Acetyl-4-[p-[[2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine. CAS-65277-42-1 (1978).

Pharmacologic Category

Anti-infective Agents; Antifungals; Azoles. Skin and Mucous Membrane Agents; Antifungals; Azoles. (ATC-Code: D01AC08; G01AF11; J02AB02).

Mechanism of action

Alters permeability of cell wall by blocking fungal cytochrome P450. Inhibits biosynthesis of triglycerides and phospholipids by fungi. Inhibits several fungal enzymes, which results in build-up of toxic concentrations of hydrogen peroxide. Also inhibits androgen synthesis.

Therapeutic use

Treatment of susceptible fungal infections, including candidiasis, oral thrush, blastomycosis, histoplasmosis, paracoccidioidomycosis, coccidioidomycosis, chromomycosis, candiduria, chronic mucocutaneous candidiasis, as well as certain recalcitrant cutaneous dermatophytoses. Treatment of Tinea corporis, T. cruris, T. versicolor, cutaneous candidiasis, seborrheic dermatitis, dandruff.

Pregnancy and lactiation implications

Teratogenic effects noted in animal studies. There are no adequate, well-controlled studies in pregnant women. Enters breast milk (use not recommended during lactation).

Unlabeled use

Treatment of prostate cancer (androgen synthesis inhibitor).


Hypersensitivity to ketoconazole or any component of the formulation. CNS fungal infections (due to poor CNS penetration). Co-administration with ergot derivatives or cisapride contraindicated (risk of potentially fatal cardiac arrhythmias).

Warnings and precautions

Possible adrenal suppression (with high doses of ketoconazole). Ketoconazole associated with hepatotoxicity (use with caution in pre-existing hepatic impairment). Concomitant use with cisapride contraindicated (risk of ventricular arrhythmias). Some formulations may contain alcohol and propane/butane, or sulfites.



Legal Notice
Privacy Policy
Cookie Policy


Phone: +34-981-780505
Location: Sta Marta de, C. P. Babío, S/N, 15165 Bergondo, A Coruña

Copyright © 2023 WAGEM

Add to cart