Anaphylactic reactions might occur (use caution with history of severe anaphylaxis to allergens). Hepatic injury including some fatalities reported rarely. Symptomatic hypotension with or without syncope may occur. Orthostatic hypotension may occur with I.V. administration. Avoid use in bronchospastic disease. Use with caution in diabetes mellitus (might potentiate hypoglycemia and/or mask signs and symptoms, also reduce release of insulin in response to hyperglycemia). Use with extreme caution in compensated heart failure. Use with caution in hepatic impairment, myasthenia gravis, peripheral vascular disease and Raynaud’s disease (might precipitate or aggravate symptoms of arterial insufficiency), pheochromocytoma. Use with caution in history of psychiatric illness (may cause or exacerbate CNS depression). Use with caution in patients receiving anesthetic agents which decrease myocardial function. Use with caution in patients on concurrent verapamil or diltiazem (bradycardia or heart block can occur). Avoid concurrent use of both agents. Elimination of labetalol reduced in elderly patients. Avoid abrupt withdrawal.