Women of childbearing potential. Rare cases of dermatologic reactions (including Stevens-Johnson syndrome and toxic epidermal necrolysis) reported. Rare reports of hepatotoxicity, hepatic failure, and death with use. Might increase susceptibility to infection, including opportunistic pathogens. Caution when considering use in history of new/recurrent infections, with conditions which predispose patients to infections, or with chronic, latent, or localized infections. Use associated (rarely) with interstitial lung disease. Use may affect defenses against malignancies. Use with caution in prior history of significant hematologic abnormalities including bone marrow dysplasia; use associated with rare pancytopenia, agranulocytosis, and thrombocytopenia, particularly when given in combination with methotrexate or other immunosuppressive agents. Avoid use in hepatic impairment or evidence of hepatitis B or C. Use with caution in renal impairment (will increase uric acid excretion). Contraindicated during pregnancy. Live vaccines should not be given concurrently.