CNS stimulation may occur (tremor, restlessness, confusion, and very rarely hallucinations or seizures). Potential for seizures, although very rare, may be increased with concomitant NSAID therapy. Use with caution in individuals at risk of seizures, with known or suspected CNS disorders or renal dysfunction. Use caution to avoid possible photosensitivity reactions during and for several days following fluoroquinolone therapy. Use with caution in renal impairment. Severe hypersensitivity reactions, including anaphylaxis, occurred with quinolone therapy. If allergic reaction occurs (itching, urticaria, dyspnea or facial edema, loss of consciousness, tingling, cardiovascular collapse), discontinue drug immediately. Prolonged use may result in superinfection; pseudomembranous colitis may occur and should be considered in all patients who present with diarrhea. Rare incidence of peripheral neuropathy documented; discontinue if patient experiences symptoms of neuropathy including pain, burning, tingling, weakness or other sensory abnormalities. Tendon inflammation and/or rupture reported (risk may be increased with concurrent corticosteroids, particularly in the elderly). Quinolones may exacerbate myasthenia gravis; use with caution (rare, potentially life-threatening weakness of respiratory muscles may occur); avoid use in children <18 years of age due to association of other quinolones with transient arthropathies.