Loracarbef
- Atc Codes:J01DC08
- CAS Codes:121961-22-6#76470-66-1
- PHARMGKB ID:121961-22-6#76470-66-1
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Inhibits
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Germany: Lorafem; Greece: Lorbef; Italy: Carbem; Sweden: Lorabid.
Drug combinations
Chemistry
Loracarbef: C~16~H~16~ClN~3~O~4~ H~2~O. Mw: 367.78. (1) 1-Azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[(aminophenylacetyl)amino]-3-chloro-8-oxo-, monohydrate, [6R-[6a,7b(R*)]]-; (2)(6R,7S)-7-[(R)-2-Amino-2-phenylacetamido]-3-chloro-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, monohydrate. CAS-121961-22-6; CAS-76470-66-1 (anhydrous)(1989).
Pharmacologic Category
Antibacterials; Second Generation Cephalosporins; Carbacephem Antibiotic. (ATC-Code: J01DC08).
Mechanism of action
Inhibits bacterial cell wall synthesis by binding to one or more penicillin-binding proteins. Inhibits final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis.
Therapeutic use
Treatment of mild-to-moderate community-acquired infections of respiratory tract, skin and skin structure, and urinary tract caused by susceptible S. pneumoniae, H. influenzae, M. catarrhalis, S. aureus, S. pyogenes, and E. coli.
Pregnancy and lactiation implications
Unknown whether distributed into milk (use with caution).
Unlabeled use
Contraindications
Hypersensitivity to loracarbef, any component of the formulation, or cephalosporins.
Warnings and precautions
Possible emergence and overgrowth of nonsusceptible organism. Hypersensitivity reactions such as anaphylaxis, serum sickness-like reactions, Stevens-Johnson syndrome, and toxic epidermal necrolysis reported. Partial cross-allergenicity among β-lactam antibiotics, including penicillins, cephalosporins, and cephamycins. Use with caution in hypersensitivity to penicillins (contraindicated in those hypersensitive to cephalosporins). Use with caution in history of GI disease, particularly colitis. Use with caution in renal impairment.