Loratadine
- Atc Codes:R06AX13
- CAS Codes:79794-75-5
- PHARMGKB ID:79794-75-5
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Caution and personalized dose adjustment in patients with the following genotypes
- Other genes that may be involved
- Substrate of
- Inhibits
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Allernon, Clarityn, Lorano, Loratadin; Belgium: Claritine, Loratadine, Rupton, Sanelor; Bulgaria: Claritine, Erolin, Histalor, Lorano, Loratadin; Cyprus: Claritine, Horestyl, Lorytec, Remidine, Ticevis, Utel; Czech Republic: Claritine, Erolin, Flonidan, Loratadin, Roletra; Denmark: Clarityn, Loratadin; Estonia: Claritine, Loratadin, Rinolan; Finland: Clarityn, Histadin, Loratadin, Tuulix; France: Clarityne, Loratadine, Zaprilis; Germany: Clarityne, Lisino, Lobeta, Lora Basics, Lora-ADGC, Lora-Lich, Lora-Puren, Loraderm, Loralerg, Lorano, Loratad, Loratadin, Loratadura, Loravis; Greece: Biliranin, Bollinol, Clarityne, Helporigin, Horestyl, Igir, Latoren, Lora, Loratab, Loratadine, Novacloxab, Ralinet, Utel, Zelmar; Hungary: Claritine, Erulin, Flonidan, Lorano, Lorastine, Loratadin, Roletra; Ireland: Clarityn, Histaclar, Lorat; Italy: Alorin, Clarityn, Fristamin, Loratadina; Latvia: Claritine, Erolin; Lithuania: Claritine, Erolin, Lomilan, Loradon, Loratin; Luxembourg: Claritine, Sanelor; Malta: Clarityn; Netherlands: Allerfre, Claritine, Erolin, Lorastad, Loratadine; Poland: Alektin, Aleric, Alesklar, Claritine, Flonidan, Lorafast, Loralek, Loratadine, Loratadyna, Loratan, Loratine, Loravin, Rotadin; Portugal: Alerdaune, Alertrin, Claritine, Evertine, Histadin, Loratadina, Profenox, Zolargene; Romania: Claritine, Flonidan, Loratadin, Loratadina, Loratimed, Pressing, Roletra, Symphoral; Slovakia: Claritine, Erolin, Flonidan, Loratadin, Rinolan; Slovenia: Claritine, Flonidan, Florgan, Rinolan; Spain: Alergoratio, Civeran, Clarityne, Loratadina; Sweden: Clarityn, Loratadin, Versal; UK: Clarityn.
North America
Canada: Claritin, Loratadine; USA: Alavert, Claritin, Loratadine.
Latin America
Argentina: Aerotina, Alergiano, Alergipan, Alermuc, Alerpriv, Algistop, Bedix, Benadryl 24, Biloina, Clarityne, Devedryl, Dexitis, Excelentia Antialergico, Hisplex, Lisaler, Loisan, Loralivio, Loratadina, Loremex, Megalorat, Mudantil L, Niltro, Nularef, Omega 100L, Pulmosan Aller, Sinaler, Tabcin Alergia, Vagran; Brazil: Alergaliv, Claritin, Cloratadd, Histadin, Loradine, Loralerg, Loranil, Loratadina, Loratamed, Loremix, Loritil; Mexico: Alerfin, Aludix, Antilergal, Biodin, Biolorat, Clarityne, Curyken, Dimegan, Dissen, Ditana, Doralan, Dotagil, Dymaten, Efectine, Fartadin, Grimeral, Histina, Histox, HL-Ysta, Inigrin, Laritol, Lertamine, Liferamin, Loratadina, Lotinex, Lotos, Lovarin, Neoalexil, Nidatar, Quimtadine, Rodakin, Roletra, Serralsina, Sitinir, Urtisin.
Asia
Japan: Claritin.
Drug combinations
Loratadine and Ambroxol
Loratadine and Betamethasone
Loratadine and Dexamethasone
Loratadine and Pseudoephedrine
Loratadine, Acetaminophen, and Pseudoephedrine
Loratadine, Acetaminophen, Bromhexine, and Pseudoephedrine
Chemistry
Loratadine: C~22~H~23~ClN~2~O~2~. Mw: 382.88. (1) 1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-, ethyl ester; (2) Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylate. CAS-79794-75-5 (1986).
Pharmacologic Category
Second Generation Antihistamines; Histamine H~1~ Antagonist. (ATC-Code: R06AX13).
Mechanism of action
Long-acting tricyclic antihistamine with selective peripheral histamine H~1~-receptor antagonistic properties.
Therapeutic use
Relief of nasal and non-nasal symptoms of seasonal allergic rhinitis. Treatment of chronic idiopathic urticaria.
Pregnancy and lactiation implications
Not found teratogenic in animal studies. Use during pregnancy only if clearly needed.
Unlabeled use
Contraindications
Hypersensitivity to loratadine or any component of the formulation.
Warnings and precautions
Use with caution in hepatic or renal impairment. Some products may contain phenylalanine.