Mafenide
- Atc Codes:D06BA03
- CAS Codes:13009-99-9
- PHARMGKB ID:13009-99-9
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
North America
USA: Sulfamylon.
Drug combinations
Chemistry
Mafenide Acetate: C~7~H~10~N~2~O~2~S C~2~H~4~O~2~. Mw: 246.28. (1) Benzenesulfonamide, 4-(aminomethyl)-, monoacetate; (2) α-Amino-p-toluenesulfonamide monoacetate. CAS-13009-99-9.
Pharmacologic Category
Local Anti-infectives, Miscellaneous. Topical Antibiotic. (ATC-Code: D06BA03).
Mechanism of action
Interferes with bacterial folic acid synthesis through competitive inhibition of p-aminobenzoic acid.
Therapeutic use
Adjunctive antibacterial agent for second- and third-degree burns and for use under moist dressings over meshed autografts on excised burn wounds (solution).
Pregnancy and lactiation implications
Teratogenic effects not observed in animal studies using oral preparation. Safety and efficacy not established in pregnant women.
Unlabeled use
Contraindications
Hypersensitivity to mafenide or any component of the formulation.
Warnings and precautions
Use in sulfonamide allergy contraindicated. Should be applied with caution in hypersensitivity to mafenide. Fungal or bacterial superinfection, including C. difficile-associated diarrhea and pseudomembranous colitis observed with prolonged use. Use caution in G6PD deficiency (might increase risk of DIC or hemolytic anemia), and in renal impairment. Some dosage forms contain sulfites (might cause allergic reactions). For external use only.