Table of contents

  • Brand Names
  • Drug Combinations
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Genes that may be involved
  • Substrate of
  • Inhibits
  • Dosage

Brand Names


Belgium: Prioderm, Radikal; Cyprus: Prioderm; Denmark: Prioderm; Estonia: Malation; Finland: Prioderm; Ireland: Derbac, Malathion, Prioderm, Suleo; Luxembourg: Malthionex, Prioderm, Radikal; Malta: Derbac; Netherlands: Prioderm; Sweden: Prioderm; UK: Derbac, Prioderm.

North America

USA: Malathion, Ovide.

Drug combinations

Malathion, Permethrin, and Piperonyl


Malathion: C~10~H~19~O~6~PS~2~. Mw: 330.36. (1) Butanedioic acid, [(dimethoxyphosphinothioyl)-thio]-, diethyl ester, (±)-; (2) Diethyl (±)-mercaptosuccinate, S-ester with O,O-dimethyl phosphorodithioate. CAS-121-75-5.

Pharmacologic Category

Skin and Mucous Membrane Agents; Scabicides and Pediculicides. Topical Antiparasitic Agent. (ATC-Code: P03AX03).

Mechanism of action

Active in vitro and in vivo against Pediculus humanus var. capitis (head louse) and its nits (eggs) and Phthirus pubis (pubic or crab louse). Also active against Sarcoptes scabiei, causative agent of scabies. Might be active against some P. capitis resistant to permethrin and pyrethrins.

Therapeutic use

Treatment of head lice and their ova.

Pregnancy and lactiation implications

No evidence of teratogenicity in animal models. Use (or handle) during pregnancy only if clearly needed.

Unlabeled use


Hypersensitivity to malathion or any component of the formulation. Use in neonates and/or infants.

Warnings and precautions

Might be irritating to skin and scalp. Contraindicated in infants and neonates (increased absorption of malathion). For topical use only. Lotion is flammable.



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