Meclofenamate

Table of contents

  • Brand Names
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Toxicological Effects
  • Genes that may be involved
  • Drug Interactions
  • Nutrition/Nutraceutical Interactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names

North America

Canada: Meclomen; USA: Meclofenamate.

Drug combinations

Chemistry

Meclofenamate Sodium: C~14~H~10~Cl~2~NNaO~2~.H~2~O. Mw: 336.15. (1) Benzoic acid, 2-[(2,6-dichloro-3-methylphenyl)amino]-, monosodium salt, monohydrate; (2) Monosodium N-(2,6-dichloro-m-tolyl)anthranilate monohydrate. CAS-6385-02-0; CAS-644-62-2 (meclofenamic acid)(1978).

Pharmacologic Category

Analgesics and Antipyretics; Nonsteroidal Anti-inflammatory Agents; Cyclooxygenase-2 (COX-2) Inhibitors. (ATC-Code: M01AG04; M02AA18).

Mechanism of action

Inhibits cyclooxygenase-1 (COX-1/PTGS1) and COX-2/PTGS2. Exhibits anti-inflammatory, analgesic, and antipyretic activity.

Therapeutic use

Treatment of inflammatory disorders, arthritis, mild to moderate pain, dysmenorrhea.

Pregnancy and lactiation implications

May cause premature closure of ductus arteriosus in 3^rd^ trimester of pregnancy. Use not recommended in nursing women.

Unlabeled use

Contraindications

Hypersensitivity to meclofenamate, aspirin, other NSAIDs, or any component of the formulation. Perioperative pain in setting of coronary artery bypass graft surgery.

Warnings and precautions

Anaphylactoid reactions might occur (do not use in asthma, bronchospasm, rhinitis, or urticaria with NSAID or aspirin therapy). Platelet adhesion and aggregation might be decreased. Might prolong bleeding time. Anemia might occur. NSAIDs associated with increased risk of adverse cardiovascular thrombotic events, including myocardial infarction, stroke, and new onset or worsening of pre-existing hypertension (use caution with fluid retention, heart failure, or hypertension). NSAIDs might increase risk of gastrointestinal irritation, inflammation, ulceration, bleeding, and perforation (use caution with history of bleeding or ulcers, concurrent therapy with aspirin, anticoagulants and/or corticosteroids, smoking, use of alcohol, elderly or debilitated patients). NSAIDs might cause serious skin adverse events including exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis. Do not administer in aspirin-sensitive asthma (severe bronchospasm might occur), and use caution in other forms of asthma. Use contraindicated for treatment of perioperative pain in setting of coronary artery bypass graft surgery. Use with caution in decreased hepatic function. Patients with impaired renal function, dehydration, heart failure, liver dysfunction, those taking diuretics, and ACEIs, and the elderly are at greater risk of renal toxicity. Not recommended for use in advanced renal disease. Long-term NSAID use may result in renal papillary necrosis. The elderly are at increased risk for adverse effects (especially peptic ulceration, CNS effects, renal toxicity). Withhold prior to surgical or dental procedures.

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