Table of contents

  • Brand Names
  • Drug Combinations
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Unlabeled Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Caution and personalized dose adjustment in patients with the following genotypes
  • Other genes that may be involved
  • Drug Interactions
  • Nutrition/Nutraceutical Interactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names


Austria: Arcaphage, Diabetex, Glucophage, Meglucon, Metformin; Belgium: Glucophage, Metformax, Metformine; Bulgaria: Glibomet, Glucophage, Meglucon, Metfogamma, Metformin, Neoformin, Normaglic, Siofor; Cyprus: Brot, Glucophage, Glyformin, Metforal, Metformin, Neomid; Czech Republic: Adimet, Diaphage, Glucophage, Gluformin, Glumetsan, Langerin, Metfirex, Metfogamma, Metfogen, Metformin, Normaglyc, Siofor, Stadamet; Denmark: Metformin, Orabet-Hexal; Estonia: Glumetsan, Metfogamma, Metforal, Metformin, Stadamet; Finland: Diformin Retard, Glucophage, Metforem, Metformin, Metgol, Oramet; France: Diabamyl, Glucophage, Metformine; Germany: Biocos, Bonformin, Diabesin, Diabetase, Glucobon, Glucofree, Glucophage, Juformin, Mediabet, Meglucon, Mekoll, Mescorit, Met, Metfin, Metfogamma, Metfor, Metform, Metformdoc, Metformin, Metkar, Metnit, Metsop, Metsurrir, Mettas, Siofor; Greece: Formin, Glucofree, Glucophage, Glucoplus, Metforil, Metformin, Metformine, Sukontrol; Hungary: Adimet, Meforal, Meglucon, Merckformin, Metfogamma, Metformin, Metrivin, Normaglyc, Stadamet; Ireland: Bellformin, Gerformin, Glucophage, Metformin, Metophage; Italy: Glucophage, Metbay, Metfonorm, Metforal, Metforalmille, Metformina; Latvia: Formetic, Glucophage, Glumetsan, Metfogamma, Metforal, Metformin, Normaglyc, Stadamet; Lithuania: Glumetsan, Metfogamma, Metforal, Metformin, Normaglyc, Stadamet; Luxembourg: Glucophage; Malta: Brot, Glyformin, Glucophage, Metformin, Metforal; Netherlands: Metformine; Poland: Etform, Formetic, Glucophage, Gluformin, Glumetsan, Mefrin, Metfogamma, Metformax, Metformin, Metformina, Metifor, Metral-Warszawskie Zakł.Farm., Normaglic, Siofor, Stadamet; Portugal: Glucophage, Mekoll, Metformina, Risidon, Stagid; Romania: Altroin, Diaformin, Diguan, Dipimet, Formiran, Glucophage, Medifor, Meguan, Metfogamma, Metformin, Normaglyc, Siofor; Slovakia: Glucophage, Glumetsan, Metfogamma, Metfogen, Metformin, Normaglyc, Siofor, Stadamet; Slovenia: Aglurab, Glucophage, Metfogamma, Siofor; Spain: Dianben, Metformina; Sweden: Glucophage, Metformin; UK: Glucophage, Metformin.

North America

Canada: Glucophage, Glumetza, Glycon, Metformin; USA: Fortamet, Glucophage, Glumetza, Metformin, Riomet.

Latin America

Argentina: Baligluc, Diab Dos, Diabesil, Duburina, Glucaminol, Glucogood, Glucophage, Islotin, Mectin, Medobis, Melgib, Metforal, Metformin, Metformina, Metglucon, Oxemet, Redugluc; Brazil: Diaformin, Dimefor, Formyn, Glicefor, Glicomet, Glifage, Glucoformin, Meguanin, Metformed, Metformina, Merformix, Neo Metformin, Teutoformin; Mexico: Aglumet, Anglucid, Apozemia, Dabex, Debeone, Dimefor, Dinamel, Ficonax, Forlucyl, Glucotec, Glunovag, Harbamind, Ifor, Meglubet, Melbexa, Metbax, Metformina, Metixor, Mifelar, Pharmafet, Predial, Sibet.


Japan: Glycoran, Medet, Melbin, Metrion, Nelbis.

Drug combinations

Metformin and Chlorpropamide

Metformin and Glipizide

Metformin and Glyburide

Metformin and Pioglitazone

Metformin and Repaglinide

Metformin and Rosiglitazone

Metformin and Saxagliptin

Metformin and Sitagliptin

Metformin and Vildagliptin


Metformin Hydrochloride: C~4~H~11~N~5~ HCl. Mw: 165.62. (1) Imidodicarbonimidic diamide, N,N-dimethyl-, monohydrochloride; (2) 1,1-Dimethylbiguanide monohydrochloride. CAS-1115-70-4 (1995).

Pharmacologic Category

Antidiabetic Agents; Biguanides. (ATC-Code: A10BA02).

Mechanism of action

Decreases hepatic glucose production, decreasing intestinal absorption of glucose and improves insulin sensitivity (increases peripheral glucose uptake and utilization).

Therapeutic use

Management of type 2 diabetes mellitus (non-insulin-dependent) as monotherapy. In adults, may be used concomitantly with sulfonylurea or insulin to improve glycemic control.

Pregnancy and lactiation implications

Adverse events not observed in animal studies. Metformin crosses placenta. Insulin is drug of choice for control of diabetes mellitus during pregnancy. Use not recommended during lactation.

Unlabeled use

Gestational diabetes mellitus. Polycystic ovary syndrome.


Hypersensitivity to metformin or any component of the formulation. Renal disease or renal dysfunction (serum creatinine ≥1.5 mg/dL in males or ≥1.4 mg/dL in females) or abnormal creatinine clearance from any cause, including shock, acute myocardial infarction, or septicemia. Acute or chronic metabolic acidosis with or without coma (including diabetic ketoacidosis). Temporarily discontinue in patients undergoing radiologic studies in which intravascular iodinated contrast media are utilized.

Warnings and precautions

Lactic acidosis is rare, but potentially severe consequence of therapy with metformin. Risk of accumulation and lactic acidosis increases with degree of impairment of renal function. Use caution in congestive heart failure, particularly in unstable or acute heart failure (risk of lactic acidosis may be increased secondary to hypoperfusion). Avoid use in impaired liver function (potential for lactic acidosis). Metformin is substantially excreted by kidney (patients with renal function below limit of normal for their age should not receive therapy). Metformin should be withheld in dehydration and/or prerenal azotemia. Metformin should not be initiated in patients ≥80 years of age unless normal renal function confirmed. Ethanol might potentiate effect of metformin on lactate metabolism (excessive acute or chronic ethanol use should be avoided). Therapy should be temporarily discontinued prior to or at the time of intravascular administration of iodinated contrast media (potential for acute alteration in renal function). Therapy should be suspended for any surgical procedures.



Legal Notice
Privacy Policy
Cookie Policy


Phone: +34-981-780505
Location: Sta Marta de, C. P. Babío, S/N, 15165 Bergondo, A Coruña

Copyright © 2023 WAGEM

Add to cart