Prolonged use and/or high doses may cause peliosis hepatis or liver cell tumors. Use with caution in breast cancer (might cause hypercalcemia by stimulating osteolysis), in diabetes mellitus, in conditions influenced by edema (e.g. cardiovascular disease, migraine, seizure disorder, renal impairment), in hepatic impairment, and in elderly patients. May accelerate bone maturation in children. Discontinue with evidence of mild virilization in women.