Table of contents

  • Brand Names
  • Drug Combinations
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Unlabeled Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Genes that may be involved
  • Substrate of
  • Inhibits
  • Drug Interactions
  • Nutrition/Nutraceutical Interactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names


Austria: Anaerobex, Ariline, Metronidazol, Nidazea, Rozex, Trichex; Belgium: Flagyl, Nidazea, Rosaced, Rozex; Bulgaria: Arilin, Efloran, Flagyl, Metris, Metronidazol, Trichomonacid; Cyprus: Anabact, Colpocin-T, Dumozol, Elyzol, Flagyl, Klont, Metronidazole, Nidagyl, Norzol, Zidoval; Czech Republic: Efloran, Entizol, Metronidazol, Rosalox, Rozex; Denmark: Flagyl, Metronidazol, Rozex, Zidoval; Estonia: Arilin, Metronidazol, Metrosa, Rozex; Finland: Flagyl, Metronidazol, Rosazol, Rozex, Trikozol, Zidoval; France: Flagyl, Grinazole, Imizine, Metrocol, Metrogene, Metronidazole, Rosiced, Rozacreme, Rozagel, Rozex; Germany: Arilin, Clont, Elyzol, Flagyl, Infectoclont, Lindoplus, Macoflex, Metrobac, Metrocreme, Metronid, Metronidazol, Metronour, Metrosa, Rosiced, Rozex, Vagimid; Greece: Colpocin, Emedal, Flagolin, Flagyl, Gnostol, Metrazol, Metrogyl, Metronidazole, Robaz, Rosiced, Trichovagil, Tricodazol, Unitrim; Hungary: Klion, Metronidazol, Metrosa, Rozex, Supplin; Ireland: Flagyl, Metrogel, Metronidazole, Rozex; Italy: Deflamon, Flagyl, Metronid, Metronidazolo, Rosiced, Rozex, Vagilen, Zidoval; Latvia: Arilin, Efloran, Flazole, Klion, Metrogyl, Metronidazol, Metrosa, Rozex, Trichopol; Lithuania: Metronidazole; Luxembourg: Anaeromet, Flagyl, Metronidazole, Pharmaflex, Rozex; Malta: Colpocin, Flagyl, Klont, Meclon, Metronidazole, Rozex, Zyomet; Netherlands: Flagyl, Metronidazol, Nidazea, Rosiced, Rozex; Poland: Arilin, Grinazole, Metronidazol, Rozex; Portugal: Dumozol, Elyzol, Flagyl, Metroderme, Metronidazol, Norstene, Rodermil, Roseless, Rosiced; Romania: Flagyl, Grinazole, Metrogene, Metronidazol; Slovakia: Efloran, Entizol, Metronidazol, Metronidazole, Rozex; Slovenia: Efloran, Metronidazol, Rozamet; Spain: Flagyl, Metronidazol, Rozex; Sweden: Flagyl, Metronidazol, Robaz, Rozex, Zidoval; UK: Flagyl, Metrogel, Metrolyl, Metronidazole, Metrotop, Norzol, Rosiced, Rozex, Zidoval, Zyomet.

North America

Canada: Flagyl, Florazole, Metrogel, Metronidazole, Nidagel, Noritate, Novo-Nidazol, Rosasol; USA: Flagyl, Metrocream, Metronidazole, Noritate, Vandazole.

Latin America

Argentina: Bexón, Colpofilín, Dazotron, Etronil, Flagyl, Ginkan, Metral, Metrocev, Metrodermic, Metrolocal, Metronidazol, Nalox, Ovufem, Padet, Repligen, Rozex, Taremis, Tolbín, Tricofín; Brazil: Canderm, Candifen, Dalzolston, Flagyl, Flanizol, Helmizol, Metronidazol, Metronide, Metroniflex, Metronin, Metronix, Metroval, Metrozol, Neo Metrodazol, Odonid, Rozex; Mexico: Ameblín, Biomona, Biotazol, Dasmetrol, Dualizol, Elyzol, Epaq-Graceway, Fagizol, Fartricon, Flagenase, Flagenol, Flagepat, Flagyl, Flaxtec, Fresenizol, Lagylan, Lamblit, Messeldazol, Metricom, Metrizol, Metrobendizol, Metrocream, Metrogel, Metronidazol, Metroson, Milezzol, Nidralon, Nidrozol, Nitromidager, Ortrizol, Otrozol, Planizol, Prozolin, Samonil, Stomffler, Valpar, Vanestrín, Vertisal.


Japan: Asuzol, Flagyl.

Drug combinations

Metronidazole and Chlorquinaldol

Metronidazole and Clotrimazole

Metronidazole and Iodoquinol

Metronidazole and Miconazole

Metronidazole and Neomycin

Metronidazole and Nystatin

Metronidazole and Spiramycin

Metronidazole, Amoxicillin, and Lansoprazole

Metronidazole, Bismuth, and Tetracycline

Metronidazole, Dexamethasone, and Nystatin

Metronidazole, Lansoprazole, and Tetracycline

Metronidazole, Neomycin, and Nystatin

Metronidazole, Boric Acid, Hydrocortisone, and Nystatin

Metronidazole, Miconazole, Neomycin, and Polymyxin B

Metronidazole, Dexamethasone, Lidocaine, Neomycin, and Nystatin

Metronidazole, Gotu Kola, Hydrocortisone, Miconazole, Neomycin, and Polymyxin B


Metronidazole: C~6~H~9~N~3~O~3~. Mw: 171.15. 1H-Imidazole-1-ethanol, 2-methyl-5-nitro-. CAS-443-48-1; CAS-13182-89-3 (benzoate)(1962).

Metronidazole Hydrochloride: C~6~H~9~N~3~O~3~.HCl. Mw: 207.61. (1) 1H-Imidazole-1-ethanol, 2-methyl-5-nitro-, hydrochloride; (2) 2-Methyl-5-nitroimidazole-1-ethanol monohydrochloride. CAS-69198-10-3 (1980).

Pharmacologic Category

Amebicides. Miscellanous Antiprotozoals. Antiulcer Agents and Acid Suppressants. Skin and Mucous Membrane Agents; Antibacterials. (ATC-Code: A01AB17; D06BX01; G01AF01; J01XD01; P01AB01).

Mechanism of action

After diffusing into organism, interacts with DNA to cause loss of helical DNA structure and strand breakage resulting in inhibition of protein synthesis and cell death in susceptible organisms.

Therapeutic use

Treatment of susceptible anaerobic bacterial and protozoal infections in the following conditions: Amebiasis, symptomatic and asymptomatic trichomoniasis. Skin and skin structure infections. CNS infections. Intra-abdominal infections (as part of combination regimen). Systemic anaerobic infections. Treatment of antibiotic-associated pseudomembranous colitis, bacterial vaginosis. As part of multidrug regimen for H. pylori eradication to reduce risk of duodenal ulcer recurrence. Treatment of inflammatory lesions and erythema of rosacea.

Pregnancy and lactiation implications

Crosses placenta (carcinogenic in rats). Contraindicated for treatment of trichomoniasis during 1^st^ trimester of pregnancy, unless alternative treatment inadequate. Use only during pregnancy when benefit to mother outweighs potential risk to fetus. It is suggested to stop breast-feeding for 12-24 hours following single-dose therapy to allow excretion of dose.

Unlabeled use

Crohn’s disease.


Hypersensitivity to metronidazole, nitroimidazole derivatives, or any component of the formulation. Pregnancy (1^st^ trimester; found to be carcinogenic in rats).

Warnings and precautions

Possibly carcinogenic based on animal data. Seizures and neuropathies reported, especially with increased doses and chronic treatment (use with caution in history of seizure disorder). Prolonged use may result in fungal or bacterial superinfection, including C. difficile-associated diarrhea and pseudomembranous colitis. Use with caution in blood dyscrasias, in heart failure or other sodium-retaining states; also in liver impairment (potential accumulation), and in renal impairment (CrCl <10 mL/minute).



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