Miconazole
- Atc Codes:A01AB09#A07AC01#D01AC02#G01AF04#J02AB01#S02AA13
- CAS Codes:22832-87-7#22916-47-8
- PHARMGKB ID:22832-87-7#22916-47-8
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Substrate of
- Inhibits
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
Brand Names
Europe
Austria: Daktarin; Belgium: Daktarin, Tibozole; Bulgaria: Daktarin; Cyprus: Candiplas, Daktarin, Untano; Denmark: Brentan; Estonia: Daktarin; Finland: Daktarin; France: Daktarin, Loramyc; Germany: Daktar, Daktarin, Decomyk, Derma-Mykotral, Fungur, Gyno-Daktar, Infectosoor, Loramyc, Micobeta, Micocandida, Miconazol, Micotar, Mykoderm, Mykotin, Greece: Daktarin, Fantersol, Medacter, Mezolitan, Untano, Zimycan; Hungary: Mycosolon; Ireland: Daktarin; Italy: Andergin, Daktarin, Miconal, Micotef, Miderm, Nizacol, Prilagin; Lithuania: Daktarin; Luxembourg: Albistat, Daktar, Daktarin; Malta: Daktarin, Miconal, Zimycan; Netherlands: Dermacure, Loramyc, Miconazolnitraat, Zimycan; Poland: Gyno-Femidazol, Miconal, Mikonazol; Portugal: Daktarin, Zimycan; Romania: Dermozol, Gynozol, Medacter, Miconal, Miconazol, Mycoheal; Slovenia: Daktarin; Spain: Daktarín, Fungisdín, Pasedón; Sweden: Daktar, Loramyc, Mikonazol; UK: Daktarin, Loramyc.
North America
Canada: Micatin, Miconazole, Micozole, Monistat; USA: M-Zole, Miconazole, Monistat, Oravig.
Latin America
Argentina: Daktarín, Deralbine, Miconol, Micopul, Micotral, Micotrim, Monizol, Nedis; Brazil: Amicozol, Ciconazol, Dakgran, Daktarin, Daktazol, Ginedak, Gino-Daczol, Ginotarin, Micofim, Micogyn, Miconazol, Micotrin, Micozen, Mycosin, Vodol; Mexico: Aloid, Biodantyl, Daktarín, Falernol, Fucoderm, Fungiquim, Hipo Femme, K-Mizol, Micoffén, Miconazol, Nacomic, Neomicol, Nimicón, Niscamil, Oz Crema, Vigasil.
Asia
Japan: Amrid, Coranzoll, Feminazol, Florid, Folinade, Nitconazone, Sarasilt.
Drug combinations
Miconazole and Benzoyl Peroxide
Miconazole and Chlorhexidine Gluconate
Miconazole and Fluprednidene
Miconazole and Hydrocortisone
Miconazole and Mazipredone
Miconazole and Metronidazole
Miconazole and Zinc Oxide
Miconazole, Fluorometholone, and Neomycin
Miconazole, Gentamicin, and Hydrocortisone
Miconazole, Polymyxin B, and Prednisolone
Miconazole, Metronidazole, Neomycin, and Polymyxin B
Miconazole, Gotu Kola, Hydrocortisone, Metronidazole, Neomycin, and Polymyxin B
Chemistry
Miconazole Nitrate: C~18~H~14~Cl~4~N~2~O HNO~3~. Mw: 479.14. (1) 1H-Imidazole, 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-, mononitrate; (2) 1-[2,4-Dichloro-β-[(2,4-dichlorobenzyl)oxy]phenethyl]imidazole mononitrate. CAS-22832-87-7; CAS-22916-47-8 (miconazole)(1970).
Pharmacologic Category
Antifungals; Azoles. Topical Antifungal Agent, Vaginal Antifungal Agent. (ATC-Code: A01AB09; A07AC01; D01AC02; G01AF04; J02AB01; S02AA13).
Mechanism of action
Inhibits biosynthesis of ergosterol, damaging fungal cell wall membrane, which increases permeability causing leaking of nutrients.
Therapeutic use
Treatment of vulvovaginal candidiasis and a variety of skin and mucous membrane fungal infections.
Pregnancy and lactiation implications
Use with caution during pregnancy or lactation.
Unlabeled use
Contraindications
Hypersensitivity to miconazole or any component of the formulation.
Warnings and precautions
Irritation or sensitivity might occur. Vaginal products are petrolatum-based. For topical use only.