Naftifine
- Atc Codes:D01AE22
- CAS Codes:65473-14-5
- PHARMGKB ID:65473-14-5
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Dosage
- Pharmacokinetics and Pharmacodynamics
Brand Names
Europe
Austria: Exoderil; Bulgaria: Exoderil; Czech Republic: Exoderil; Estonia: Exoderil; Germany: Exoderil; Hungary: Exoderil; Italy: Suadian; Latvia: Exoderil; Lithuania: Exoderil; Luxembourg: Exoderil; Poland: Exoderil; Romania: Exoderil, Naftifina; Spain: Micosona.
North America
Canada: Naftin; USA: Naftin.
Drug combinations
Chemistry
Naftifine Hydrochloride: C~21~H~21~N HCl. Mw: 323.86. (E)-N-Cinnamyl-N-methyl-1- naphthalenemethylamine hydrochloride. CAS-65473-14-5.
Pharmacologic Category
Skin and Mucous Membrane Agents; Antifungals; Allylamines. Topical Antifungal Agent. (ATC-Code: D01AE22).
Mechanism of action
Although the exact mechanism of action against fungi is not known, naftifine hydrochloride appears to interfere with sterol biosynthesis by inhibiting the enzyme squalene 2,3-epoxidase. This inhibition of enzyme activity results in decreased amounts of sterols, especially ergosterol, and a corresponding accumulation of squalene in the cells.
Therapeutic use
Indicated for the topical treatment of tinea pedis, tinea cruris and tinea corporis caused by the organisms Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum.
Pregnancy and lactiation implications
Unlabeled use
Contraindications
Hypersensitivity to any of its components.
Warnings and precautions
For topical use only; not for ophthalmic use.