Use with caution in previous sensitivity to acetylsalicylic acid and phenylacetic acid derivatives, including patients who experience bronchospasm, asthma, rhinitis, or urticaria following NSAIDs or aspirin. May cause keratitis; continued use in keratitis may cause severe corneal adverse reactions, potentially resulting in loss of vision. Use with caution in predisposition to bleeding (bleeding tendencies or medications which interfere with coagulation), in diabetes mellitus (may be at risk of corneal adverse events, potentially resulting in loss of vision), in complicated ocular surgeries, corneal denervation, corneal epithelial defects, ocular surface disease, or repeat ocular surgeries (within a short timeframe)(may be at risk of corneal adverse events, potentially resulting in loss of vision), and in rheumatoid arthritis. May slow or delay healing or prolong bleeding time following surgery. Use for more than 1 day prior to surgery or for 14 days beyond surgery may increase risk and severity of corneal adverse events. Patients using ophthalmic drops should not wear soft contact lenses.