Nystatin
- Atc Codes:A07AA02#D01AA01#G01AA01
- CAS Codes:1400-61-9
- PHARMGKB ID:1400-61-9
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Adverse Reactions
- Toxicological Effects
- Genes that may be involved
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
Brand Names
Europe
Austria: Candio-Hermal, Mycostatin; Belgium: Nilstat, Nystatine; Bulgaria: Fungostatin, Nystatin; Cyprus: Mycostatin, Restatin; Czech Republic: Fungicidin; Denmark: Mycostatin; Finland: Mycostatin; France: Mycostatine; Germany: Adiclair, Biofanal, Candida Lokalicid, Candio-Hermal, Lederlind, Ledernyst, Moronal, Mykundex, Nystatin; Greece: Mycostatin, Nystamysyn; Hungary: Nystatin; Ireland: Mycostatin; Italy: Mycostatin, Nistatin; Lithuania: Nystatin; Luxembourg: Candio-Hermal, Nilstat, Nystatine; Malta: Nystan; Netherlands: Nystatine; Poland: Nystatyna; Portugal: Mycostatin; Romania: Nistatina; Slovakia: Fungicidin, Nystatin; Spain: Mycostatin; Sweden: Mycostatin; UK: Nystan, Nystatin.
North America
Canada: Nyaderm, Nystatin; USA: Mycostatin, Nilstat, Nystatin, Nystop.
Latin America
Argentina: Candermil, Candidias, Dipni, Micostatin, Neostatin, Nistamed, Nistat, Nistatina; Brazil: Canditrat, Inofungin, Kandistat, Micostal, Micostalab, Micostatin, Neo Mistatin, Neostatin, Nicostat, Nidazolin, Nistagyn, Nistatin, Nistatina, Nistaval-Nistatina, Nistomic, Tricocet; Mexico: Aponistan V, Bistatin V, Micostatin, Nistan, Nistaquin, Nistatina.
Asia
Japan: Nystatin.
Drug combinations
Nystatin and Hydrocortisone
Nystatin and Metronidazole
Nystatin and Triamcinolone
Nystatin and Zinc Oxide
Nystatin, Chlorhexidine, and Dexamethasone
Nystatin, Clobetasol, and Neomycin
Nystatin, Dexamethasone, and Metronidazole
Nystatin, Dexamethasone, and Neomycin
Nystatin, Halcinonide, and Neomycin
Nystatin, Metronidazole, and Neomycin
Nystatin, Neomycin, and Polymyxin B
Nystatin, Betamethasone, Gentamicin, and Tolnaftate
Nystatin, Boric acid, Hydrocortisone, and Metronidazole
Nystatin, Gramicidin, Neomycin, and Triamcinolone
Nystatin, Neomycin, Nitrofurazone, and Retinol (Vitamin A)
Nystatin, Neomycin, Thiostrepton, and Triamcinolone
Nystatin, Dexamethasone, Lidocaine, Metronidazole, and Neomycin
Chemistry
Nystatin: C~47~H~75~NO~17~. Mw: 926.0949. (1) 20-[(3-amino-3,6-dideoxy-D-mannopyranosyl)oxy]-4,6,8,11,12,16,18,36-octahydroxy-35,37,38-trimethyl-2,14-dioxooxacyclooctatriaconta-21,23,25,27,31,33-hexaene-17-carboxylic acid. CAS-1400-61-9.
Pharmacologic Category
Antifungals; Polyenes. Skin and Mucous Membrane Agents. (ATC-Code: A07AA02; D01AA01; G01AA01).
Mechanism of action
Binds to sterols in fungal cell membrane, changing cell wall permeability allowing for leakage of cellular contents.
Therapeutic use
Treatment of susceptible cutaneous, mucocutaneous, and oral cavity fungal infections normally caused by Candida species.
Pregnancy and lactiation implications
Use with caution in pregnancy. Does not enter breast milk (not absorbed orally).
Unlabeled use
Contraindications
Hypersensitivity to nystatin or any component of the formulation.