Palivizumab
- Atc Codes:J06BB16
- CAS Codes:188039-54-5
- PHARMGKB ID:188039-54-5
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Synagis; Belgium: Synagis; Bulgaria: Synagis; Cyprus: Synagis; Czech Republic: Synagis; Denmark: Synagis; Estonia: Synagis; Finland: Synagis; France: Synagis; Germany: Synagis; Greece: Synagis; Hungary: Synagis; Ireland: Synagis; Italy: Synagis; Latvia: Synagis; Lithuania: Synagis; Malta: Synagis; Netherlands: Synagis; Poland: Synagis; Portugal: Synagis; Romania: Synagis; Slovakia: Synagis; Slovenia: Synagis; Spain: Synagis; Sweden: Synagis; UK: Synagis.
North America
Canada: Synagis; USA: Synagis.
Latin America
Argentina: Synagis; Brazil: Synagis; Mexico: Synagis.
Asia
Japan: Synagis.
Drug combinations
Chemistry
Palivizumab: Immunoglobulin G~1~ (human-mouse monoclonal MEDI-493γ~1~-chain antirespiratory syncytial virus protein F), disulfide with human-mouse monoclonal MEDI-493κ~1~-chain, dimer. CAS-188039-54-5.
Pharmacologic Category
Antivirals; Monoclonal Antibodies. (ATC-Code: J06BB169).
Mechanism of action
Exhibits neutralizing and fusion-inhibitory activity against respiratory syncytial virus.
Therapeutic use
Prevention of serious lower respiratory tract disease caused by respiratory syncytial virus in infants and children.
Pregnancy and lactiation implications
Not for adult use. Reproduction studies not conducted.
Unlabeled use
Contraindications
History of severe prior reaction to palivizumab or any component of the formulation.
Warnings and precautions
Very rare cases of anaphylaxis observed, as well as rare cases of severe acute hypersensitivity reactions (use with caution after mild hypersensitivity reaction). Use with caution in history of bleeding disorders (including thrombocytopenia). For I.M. use only. Use caution in thrombocytopenia or any coagulation disorder.