Table of contents

  • Brand Names
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Unlabeled Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Caution and personalized dose adjustment in patients with the following genotypes
  • Drug Interactions
  • Nutrition/Nutraceutical Interactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics

Brand Names


Austria: Humatin; Belgium: Gabbroral; Greece: Humatin; Germany: Humatin; Italy: Gabbroral, Humatin, Kaman; Luxembourg: Gabbroral; Spain: Humatin.

North America

Canada: Humatin; USA: Humatin (d), Paromomycin.

Drug combinations


Paromomycin Sulfate: C~23~H~45~N~5~O~14~ H~2~SO~4~. Mw: 615.63 (base). (1) D-Streptamine, O-2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)-O-[O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-β-D-ribofuranosyl-(1→5)]-2-deoxy-, sulfate; (2) O-2,6-Diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxystreptamine sulfate. CAS-1263-89-4; CAS-7542-37-2 (paromomycin).

Pharmacologic Category

Antibacterials; Aminoglycosides. Antiprotozoals; Amebicides. (ATC-Code: A07AA06).

Mechanism of action

Acts directly on ameba. Has antibacterial activity against normal and pathogenic organisms in GI tract. Interferes with bacterial protein synthesis by binding to 30 S ribosomal subunits.

Therapeutic use

Treatment of acute and chronic intestinal amebiasis. Hepatic coma.

Pregnancy and lactiation implications

As oral paromomycin is minimally absorbed from GI tract, may be drug of choice for treatment of amebiasis or giardiasis (unlabeled use) in pregnant women. Does not enter breast milk.

Unlabeled use

Treatment of cryptosporidiosis.


Hypersensitivity to paromomycin or any component of the formulation. Intestinal obstruction.

Warnings and precautions

Prolonged use may result in fungal or bacterial superinfection, including C. difficile-associated diarrhea and pseudomembranous colitis. Use with caution in renal impairment. Use with caution in possible or proven ulcerative bowel lesions.



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