Penicillin G Benzathine
- Atc Codes:J01CE
- CAS Codes:41372-02-5#1538-09-6#61-33-6
- PHARMGKB ID:41372-02-5#1538-09-6#61-33-6
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Caution and personalized dose adjustment in patients with the following genotypes
- Other genes that may be involved
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Retarpen; Belgium: Penadur; Cyprus: Retarpen; Czech Republic: Pendepon, Retarpen; Denmark: Leomypen; France: Extencilline; Germany: Pendysin, Tardocillin; Greece: Penadur; Italy: Wycillina; Luxembourg: Penadur; Netherlands: Penadur, Penidural; Poland: Debecylina, Retarpen, Taropen; Portugal: Lentocilin, Penadur; Spain: Benoral, Benzetacil.
North America
Canada: Bicillin; USA: Bicillin.
Latin America
Argentina: Benzetacil, Galtamicina, Pen Di Ben, Penicilina G Benzatina, Penicilina G Benzatinica, Retarpén; Brazil: Bactopén, Benzatrón, Benzetacil, Benzilpenicilina Benzatina, Bepebén, Longacilín, Pencil B; Mexico: Bencelín, Benzatina Bencilpenicilina, Benzetacil, Ipenxín, Lentopenil, Unicil.
Asia
Japan: Bicillin G.
Drug combinations
Penicillin G Benzathine and Penicillin G Procaine
Chemistry
Penicillin G Benzathine: (C~16~H~18~N~2~O~4~S)~2~ C~16~H~20~N~2~ 4H~2~O. Mw: 981.18. (1) 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-, [2S-(2α,5α,6β)]-, compd. with N,N’-bis(phenylmethyl)-1,2-ethanediamine (2:1), tetrahydrate; (2)(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid compound with N,N’-dibenzylethylenediamine (2:1), tetrahydrate. CAS-41372-02-5; CAS-1538-09-6 (anhydrous); CAS-61-33-6 (penicillin G).
Pharmacologic Category
Natural Penicillins. (ATC-Code: J01CE).
Mechanism of action
Interferes with bacterial cell wall synthesis during active multiplication, causing cell wall death and resultant bactericidal activity against susceptible bacteria.
Therapeutic use
Active against some Gram-positive organisms, a few Gram-negative organisms such as Neisseria gonorrhoeae, and some anaerobes and spirochetes. Used in treatment of syphilis. Used only for treatment of mild-to-moderately severe infections caused by organisms susceptible to low concentrations of penicillin G or for prophylaxis of infections caused by these organisms.
Pregnancy and lactiation implications
Adverse events not observed in animal studies. Penicillin crosses placenta and distributes into amniotic fluid. No evidence of adverse fetal effects after penicillin use during pregnancy in humans. Penicillin G is drug of choice for treatment of syphilis during pregnancy. Caution when administering penicillin to nursing women.
Unlabeled use
Contraindications
Hypersensitivity to penicillin or any component of the formulation.
Warnings and precautions
Serious and occasionally severe or fatal hypersensitivity (anaphylactoid) reactions reported, especially with history of β-lactam hypersensitivity, history of sensitivity to multiple allergens, or previous IgE-mediated reactions (use with caution in asthmatic patients). Prolonged use may result in fungal or bacterial superinfection, including C. difficile-associated diarrhea and pseudomembranous colitis. Use with caution in renal impairment, and in history of seizure disorder (high levels, particularly in presence of renal impairment, may increase risk of seizures). Use not recommended to treat congenital syphilis or neurosyphilis, due to reported treatment failures and lack of published clinical data on its efficacy. Prolonged use or use associated with high serum concentrations (e.g. in renal insufficiency) may be associated with increased risk for some adverse reactions (neutropenia, hemolytic anemia, serum sickness).