Penicillin G Procaine
- Atc Codes:J01CE
- CAS Codes:6130-64-9#54-35-3#61-33-6
- PHARMGKB ID:6130-64-9#54-35-3#61-33-6
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Finland: Procaine Penicillin. G, Procapen; Germany: Jenacillin O; Hungary: Retardillin; Poland: Penicillinum Procainicum; Spain: Aqucilina, Farmaproina.
North America
Canada: Pfizerpen-AS, Wycillin; USA: Bicillin C-R, Wycillin.
Latin America
Mexico: Bencilpenicilina Procainica C/Cristalina, Benzotripén, Penprocilina, Procilín, Promizol, Robencaxil.
Drug combinations
Penicillin G Procaine and Neomycin
Penicillin G Procaine and Penicillin G Benzathine
Chemistry
Penicillin G Procaine: C~16~H~18~N~2~O~4~S C~13~H~20~N~2~O~2~ H~2~O. Mw: 588.72. (1) 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-, [2S-(2α,5α,6β)]-, compd. with 2-(diethylamino)ethyl 4-aminobenzoate (1:1) monohydrate; (2)(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid compound with 2-(diethylamino)ethyl p-aminobenzoate (1:1) monohydrate. CAS-6130-64-9; CAS-54-35-3 (anhydrous); CAS-61-33-6 (penicillin G).
Pharmacologic Category
Natural Penicillins. (ATC-Code: J01CE).
Mechanism of action
Inhibits bacterial cell wall synthesis by binding to one or more penicillin binding proteins. Bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested.
Therapeutic use
Treatment of moderately-severe infections due to Treponema pallidum and other penicillin G-sensitive microorganisms susceptible to low, but prolonged serum penicillin concentrations. To reduce incidence or progression of disease following exposure to aerolized Bacillus anthracis.
Pregnancy and lactiation implications
Adverse events not observed in animal studies. No evidence of adverse fetal effects after penicillin use during pregnancy in humans. Caution when administering penicillin to nursing women.
Unlabeled use
Contraindications
Hypersensitivity to penicillin, procaine, or any component of the formulation.
Warnings and precautions
Serious and occasionally severe or fatal hypersensitivity (anaphylactoid) reactions reported, especially with history of β-lactam hypersensitivity, history of sensitivity to multiple allergens, or previous IgE-mediated reactions (use with caution in asthmatic patients). Avoid I.V., intravascular, or intra-arterial administration (severe and/or permanent neurovascular damage may occur). Prolonged use may result in fungal or bacterial superinfection, including C. difficile-associated diarrhea and pseudomembranous colitis. Use with caution in severe renal impairment, and in history of seizure disorder (high levels, particularly in presence of renal impairment, may increase risk of seizures). Prolonged use or use associated with high serum concentrations (e.g. in renal insufficiency) may be associated with increased risk for some adverse reactions (neutropenia, hemolytic anemia, serum sickness).