May alter cardiac conduction (life-threatening arrhythmias occurred with therapeutic doses of phenothiazines). Phenothiazines may cause anticholinergic effects (constipation, xerostomia, blurred vision, urinary retention)(use with caution in decreased gastrointestinal motility, paralytic ileus, urinary retention, benign prostatic hyperplasia, xerostomia, or visual problems). Blood dyscrasias might occur (use contraindicated in bone marrow suppression). Antipsychotic use associated with esophageal dysmotility and aspiration (use with caution in risk of pneumonia). May cause extrapyramidal symptoms, including pseudoparkinsonism, acute dystonic reactions, akathisia, and tardive dyskinesia. May be associated with neuroleptic malignant syndrome (risk may be increased in Parkinson’s disease or Lewy body dementia). May cause orthostatic hypotension (use with caution in cerebrovascular disease, cardiovascular disease, hypovolemia, or concurrent medication use which may predispose to hypotension/bradycardia). Prolonged therapy may cause pigmentary retinopathy, corneal deposits, and/or changes in skin pigmentation. May cause sedation. Impaired core body temperature regulation may occur. Use with caution in severe cardiovascular disease, in narrow-angle glaucoma (may be exacerbated by cholinergic blockade), in mitral valve prolapse (may worsen), in myasthenia gravis (may be exacerbated by cholinergic blockade), and in Parkinson’s disease. Use with caution in pheochromocytoma (may worsen), in breast cancer or other prolactin-dependent tumors (elevates prolactin levels), in respiratory disease, and in risk of seizures, including patients with history of seizures, head trauma, brain damage, alcoholism, or concurrent therapy with medications which may lower seizure threshold. May mask toxicity of other drugs or conditions (e.g. intestinal obstruction, Reye’s syndrome, brain tumor) due to antiemetic effects. Effects may be potentiated when used with other sedative drugs or ethanol. Use with caution in the elderly (increased risk for developing tardive dyskinesia).