Permethrin
- Atc Codes:P03AC04
- CAS Codes:52645-53-1
- PHARMGKB ID:52645-53-1
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Substrate of
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Infectoscab; Belgium: Nix, Zalvor; Denmark: Nix; Finland: Nix; Germany: Infectomite, Infectopedicul, Infectoperm, Infectoscab, Permethrin; Greece: Nix; Hungary: Infectoscab; Ireland: Lyclear; Italy: Nix, Scabiacid, Scabianil; Luxembourg: Nix, Zalvor; Netherlands: Loxazol; Poland: Infectoscab; Portugal: Nix, Quitoso; Romania: Nix; Slovakia: Infectoscab; Slovenia: Infectoscab; Spain: Perme-Cure, Sarcop; Sweden: Nix; UK: Lyclear, Permethrin.
North America
Canada: Kwellada, Nix; USA: Elimite, Nix, Permethrin.
Latin America
Argentina: Assy, B-Jen, Capitis, Dermoper, Hair Clin, Kinderval, Kwell, Pedicrem, Witty; Brazil: Clean Hair, Keltrina, Kwell, Nedax, Pediletan, Piodrex, Pioletal; Mexico: Novo-Herklin, Scabisán.
Drug combinations
Permethrin, Malathion, and Piperonyl
Chemistry
Permethrin: C~21~H~20~Cl~2~O~3~. Mw: 391.29. (1) Cyclopropanecarboxylic acid, 3-(2,2-dichloroethenyl)-2,2-dimethyl-, (3-phenoxyphenyl)methyl ester; (2) m-Phenoxybenzyl (±)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate; (3)(±)-3-Phenoxybenzyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate. CAS-52645-53-1 (1987).
Pharmacologic Category
Skin and Mucous Membrane Agents; Scabicides and Pediculicides. Topical Antiparasitic Agent. Scabicidal Agent. (ATC-Code: P03AC04).
Mechanism of action
Inhibits sodium ion influx through nerve cell membrane channels in parasites resulting in delayed repolarization and thus paralysis and death of pest.
Therapeutic use
Single-application treatment of infestation with Pediculus humanus capitis (head louse) and its nits or Sarcoptes scabiei (scabies). Prophylactic use during epidemics of lice.
Pregnancy and lactiation implications
Use during pregnancy only if clearly needed. Unknown whether distributed into milk (use caution).
Unlabeled use
Contraindications
Hypersensitivity to pyrethyroid, pyrethrin, chrysanthemums, or any component of the formulation. Lotion contraindicated for use in infants <2 months of age.
Warnings and precautions
Treatment may temporarily exacerbate skin irritation (itching, redness, and swelling). For external use only. May cause breathing difficulty or asthmatic episode in susceptible individuals. 5% cream contains formaldehyde 0.1% as preservative, which may cause contact dermatitis.