Piperazine
- Atc Codes:P02CB01
- CAS Codes:110-85-0#41372-10-5#144-29-6
- PHARMGKB ID:110-85-0#41372-10-5#144-29-6
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Substrate of
- Inhibits
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Bulgaria: Helmicid; Finland: Kihomato; France: Piperazine, Vermifuge; Italy: Citropiperazina, Piper; Portugal: Pipermel, Pipertox; Spain: Vermi.
North America
Canada: Formule, Piperazinum.
Latin America
Mexico: Lu-Peracina, Overpón, Piperazil, Pipergress, Pirzinol, Vermin-Streger.
Asia
Japan: Camin, Piperazine.
Drug combinations
Chemistry
Piperazine: C~4~H~10~N~2~. Mw: 86.14. CAS-110-85-0.
Piperazine Citrate: (C~4~H~10~N~2~)~3~ 2C~6~H~8~O~7~ xH~2~O. Mw: 642.65 (anhydrous). Piperazine, 2-hydroxy-1,2,3-propanetricarboxylate (3:2), hydrate. CAS-41372-10-5; CAS-144-29-6 (anhydrous).
Pharmacologic Category
Antihelmintics. (ATC-Code: P02CB01).
Mechanism of action
Causes muscle paralysis of roundworm by blocking effects of acetylcholine at neuromuscular junction.
Therapeutic use
Treatment of pinworm and roundworm infections (used as alternative to first-line agents, mebendazole, or pyrantel pamoate).
Pregnancy and lactiation implications
Use with caution during pregnancy or lactation.
Unlabeled use
Contraindications
Hypersensitivity to piperazine or any component of the formulation. Seizure disorders. Liver or kidney impairment.
Warnings and precautions
Use with caution in anemia, and in malnutrition. Avoid prolonged use especially in children.