Table of contents

  • Brand Names
  • Chemistry
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Genes that may be involved
  • Substrate of
  • Inhibits
  • Drug Interactions
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names


Bulgaria: Helmicid; Finland: Kihomato; France: Piperazine, Vermifuge; Italy: Citropiperazina, Piper; Portugal: Pipermel, Pipertox; Spain: Vermi.

North America

Canada: Formule, Piperazinum.

Latin America

Mexico: Lu-Peracina, Overpón, Piperazil, Pipergress, Pirzinol, Vermin-Streger.


Japan: Camin, Piperazine.

Drug combinations


Piperazine: C~4~H~10~N~2~. Mw: 86.14. CAS-110-85-0.

Piperazine Citrate: (C~4~H~10~N~2~)~3~ 2C~6~H~8~O~7~ xH~2~O. Mw: 642.65 (anhydrous). Piperazine, 2-hydroxy-1,2,3-propanetricarboxylate (3:2), hydrate. CAS-41372-10-5; CAS-144-29-6 (anhydrous).

Pharmacologic Category

Antihelmintics. (ATC-Code: P02CB01).

Mechanism of action

Causes muscle paralysis of roundworm by blocking effects of acetylcholine at neuromuscular junction.

Therapeutic use

Treatment of pinworm and roundworm infections (used as alternative to first-line agents, mebendazole, or pyrantel pamoate).

Pregnancy and lactiation implications

Use with caution during pregnancy or lactation.

Unlabeled use


Hypersensitivity to piperazine or any component of the formulation. Seizure disorders. Liver or kidney impairment.

Warnings and precautions

Use with caution in anemia, and in malnutrition. Avoid prolonged use especially in children.



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