Praziquantel
- Atc Codes:P02BA01
- CAS Codes:55268-74-1
- PHARMGKB ID:55268-74-1
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Unlabeled Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Substrate of
- Inhibits
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
Brand Names
Europe
France: Biltricide; Germany: Biltricide, Cesol, Cysticide; Greece: Biltricide, Praziquantel; Netherlands: Biltricide; Poland: Cesol.
North America
Canada: Biltricide; USA: Biltricide.
Latin America
Argentina: Prazitral; Brazil: Cestox, Cisticid; Mexico: Cesol, Cisticid, Tecprazin, Teniken.
Asia
Japan: Biltricide.
Drug combinations
Chemistry
Praziquantel: C~19~H~24~N~2~O~2~. Mw: 312.41. (1) 4H-Pyrazino[2,1-a]isoquinolin-4-one, 2-(cyclo-hexylcarbonyl)-1,2,3,6,7,11b-hexahydro-; (2) 2-(Cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one. CAS-55268-74-1 (1978).
Pharmacologic Category
Anti-infective Agents; Anthelmintics. (ATC-Code: P02BA01).
Mechanism of action
Increases cell permeability to calcium in schistosomes, causing strong contractions and paralysis of worm musculature leading to detachment of suckers from blood vessel walls and to dislodgment.
Therapeutic use
All stages of schistosomiasis caused by all Schistosoma species pathogenic to humans. Clonorchiasis and opisthorchiasis.
Pregnancy and lactiation implications
Use caution during pregnancy or lactation.
Unlabeled use
Cysticercosis and many intestinal tapeworms.
Contraindications
Hypersensitivity to praziquantel or any component of the formulation. Ocular cysticercosis.
Warnings and precautions
Patients with cerebral cysticercosis require hospitalization. Use with caution in severe hepatic impairment. Use caution with concurrent administration of strong cytochrome P450 inducers (therapeutic levels of praziquantel may not be achieved).