Probucol
- Atc Codes:C10AX02
- CAS Codes:23288-49-5
- PHARMGKB ID:23288-49-5
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Caution and personalized dose adjustment in patients with the following genotypes
- Other genes that may be involved
- Drug Interactions
- Dosage
Brand Names
Asia
Japan: Clafeden, Downoil, Etaclate, Evaticol, Fuckorate, Kobacus, Lipobucol, Lorelco, Lorstar, Piyocol, Probletan, Probucol, Probucolin, Prosade, Ridrase, Sacvercot, Sasupidon, Sinlestal, Swimtal, Wanil, Yestamin.
Drug combinations
Chemistry
Probucol: C~31~H~48~O~2~S~2~. Mw: 516.84. (1) Phenol, 4,4′-[(1-methylethylidene)bis(thio)]bis[2,6-bis(1,1-dimethylethyl)-; (2) Acetone bis(3,5-di-tert-butyl-4-hydroxyphenyl) mercaptole. CAS-23288-49-5 (1970).
Pharmacologic Category
Antilipemic Agents, Miscellaneous. (ATC-Code: C10AX02).
Mechanism of action
Increases fecal loss of bile acid-bound low density lipoprotein cholesterol, decreases synthesis of cholesterol and inhibits enteral cholesterol absorption.
Therapeutic use
Adjunct to dietary therapy to decrease elevated serum total and LDL-C concentrations in primary hypercholesterolemia.
Pregnancy and lactiation implications
Unlabeled use
Contraindications
Hypersensitivity to probucol or any component of the formulation. Ventricular arrhythmias.
Warnings and precautions
Prolongs QT interval and accepted as having risk of causing torsade de pointes.