Pyrantel Pamoate
- Atc Codes:P02CC01
- CAS Codes:22204-24-6#15686-83-6
- PHARMGKB ID:22204-24-6#15686-83-6
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Unlabeled Use
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Combantrin; France: Combantrin, Helmintox; Germany: Helmex; Greece: Combantrin; Italy: Combantrin; Poland: Pyrantelum; Portugal: Combantrin; Romania: Helmintox; Spain: Trilombrin.
North America
Canada: Combantrin, Pyral.
Latin America
Brazil: Ascarical; Mexico: Combantrin, Pirantrim.
Asia
Japan: Combantrin.
Drug combinations
Chemistry
Pyrantel Pamoate: C~11~H~14~N~2~S C~23~H~16~O~6~. Mw: 594.68. (1) Pyrimidine, 1,4,5,6-tetrahydro-1-methyl-2-[2-(2-thienyl)ethenyl]-, (E)-, compd. with 4,4′-methylenebis[3-hydroxy-2-naphthalenecarboxylic acid] (1:1); (2)(E)-1,4,5,6-Tetrahydro-1-methyl-2-[2-(2-thienyl)vinyl]pyrimidine 4,4′-methylenebis[3-hydroxy-2-naphthoate] (1:1). CAS-22204-24-6; CAS-15686-83-6 (pyrantel)(1969).
Pharmacologic Category
Anti-infective Agents, Anthelmintics. (ATC-Code: P02CC01).
Mechanism of action
Causes release of acetylcholine and inhibits cholinesterase. Acts as depolarizing neuromuscular blocker, paralyzing helminths.
Therapeutic use
Treatment of pinworms (Enterobius vermicularis) and roundworms (Ascaris lumbricoides).
Pregnancy and lactiation implications
Unlabeled use
Treatment of whipworms (Trichuris trichiura) and hookworms (Ancylostoma duodenale).
Contraindications
Hypersensitivity to pyrantel pamoate or any component of the formulation.
Warnings and precautions
Use with caution in anemia, hepatic impairment, malnutrition, and pregnancy. Pinworm infections easily spread to others.