Pyridoxine (Vitamin B6)
- Atc Codes:A11HA02
- CAS Codes:58-56-0#65-23-6
- PHARMGKB ID:58-56-0#65-23-6
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Unlabeled Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Caution and personalized dose adjustment in patients with the following genotypes
- Other genes that may be involved
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Vit. B6; Belgium: Pyridoxine, Vitamine B6; Bulgaria: Vitamin B6; Finland: Vita-B6; France: Becilan, Dermo 6, Pyridoxine, Vitamine B6; Germany: B6-Asmedic, B6-Vicotrat, Bonasanit, Novirell Pyragamma, Pyridoxin,Vitamin B6; Greece: 3VB, Allstam, Becilan, Benadon, Besix, Bexivit, Pedixine, Piridoxine, Vitamin B, Vitamine B6, Vitesix; Hungary: Vitamin B6; Italy: Benadon, Bivit, Farmobion B6, Glutarase, Memosprint, Xanturenasi; Luxembourg: Bedoxine, Pyridoxine; Poland: Vitaminum B6; Portugal: Benadon, Piridoxina; Romania: Pyridoxin, Vitamina B6; Slovakia: Pyridoxin; Spain: Benadón; Sweden: Benadon, Pyridoxin; UK: Pyridoxine.
North America
Canada: Mega B6, Pyridoxine, Pyridoxinum, Vit B6, Vitamin B6; USA: Pyridoxine.
Latin America
Argentina: Benadón, Tanvimil B6; Brazil: Vit B6, Seis-B.
Asia
Japan: Actamin B6, Aderoxin, B-Six, Vitamin B6.
Drug combinations
Pyridoxine and Doxylamine
Pyridoxine and Isoniazid
Pyridoxine, Dexamethasone, and Niacinamide
Pyridoxine, Chlorpromazine, Procaine, and Scopolamine
Pyridoxine, D-Panthenol, Pilocarpine, and Salicylic Acid
Pyridoxine, Carisoprodol, Dexamethasone, Hydroxocobalamin (Vitamin B~12a~), and Piroxicam
Other Pyridoxine combinations: Acetaminophen; Acorus calamus; Alchemilla vulgaris; Arabic Gum; Ascorbic Acid (Vitamin C); Beta Carotene; Beta vulgaris; Biotin (Vitamin B~7~); Caffeine, Calcium Carbonate; Calcium Citrate; Calcium Lactate; Calcium Phosphate (Tribasic); Carisoprodol, Cholecalciferol (Vitamin D~3~); Cimicifuga racemosa; Cinchona pubescens; Citric Acid; Coenzyme A; Colchicum autumnale; Conium maculatum; Cornmeal; Cyanocobalamin (Vitamin B~12~); Deanolorotat; Dexamethasone; Dexpanthenol; Equisetum arvense; Ergocalciferol (Vitamin D~2~); Erythrosine Dye; Fabiana imbricate; Ferrous Fumarate; Ferrous Sulfate; Fluoride; Folic Acid (Vitamin B~9~); Fumaric Acid; Galium aparine; Gelsemium sempervirens; Ginkgo biloba; Ginseng Root; Hawthorn Fruit; Hepar *bovis; Histamine; Hydrastis canadensis; Hydroxocobalamin (Vitamin B~12a~); Iron; Lien fetalis bovis; Magnesium; Magnesium L-Lactate; Magnesium Oxide; Malic Acid; Malt Extract; Manganese; Manital Wax; Meclizine; Milk Protein; Motherwort Herb; Natural Fiber; Niacin (Vitamin B~3~); Niacinamide; Oatmeal; Pancreas bovis; Pantothenic Acid (Vitamin B~5~); Phytonadione (Vitamin K~1~); Podophyllum peltatum; Pollen; Propyphenazone; Pseudognaphalium obtusifolium; Quinine; Racemic Methionine; Retinol (Vitamin A); Riboflavin (Vitamin B~2~); Rice Flour; Rutoside; Saccharomyces cerevisiae; Sepia officinalis; Sodium Benzoate, Soya Lecithin; Succinic Acid; Sugar; Sulfur; Symphytum officinale; Thiamine (Vitamin B~1~); Tocopherol (Vitamin E~1~); Valerian Root; Vegetable Oil; Wheat; Whey Protein; Zinc*
Chemistry
Pyridoxine Hydrochloride: C~8~H~11~NO~3~ HCl. Mw: 205.64. (1) 3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-, hydrochloride; (2) Pyridoxol hydrochloride. CAS-58-56-0; CAS-65-23-6 (pyridoxine).
Pharmacologic Category
Vitamins; Vitamin B Complex. (ATC-Code: A11HA02).
Mechanism of action
Precursor to pyridoxal, which functions in metabolism of proteins, carbohydrates, and fats. Pyridoxal also aids in release of liver- and muscle-stored glycogen and in synthesis of GABA (within CNS) and heme.
Therapeutic use
Prevention and treatment of vitamin B~6~ deficiency, pyridoxine-dependent seizures in infants.
Pregnancy and lactiation implications
Caution if parenteral preparation used in nursing women.
Unlabeled use
Treatment and prophylaxis of neurological toxicities (i.e. seizures, coma) associated with isoniazid, hydrazine, and Gyromitrin-containing mushroom (false morel) overdose/toxicity.
Contraindications
Hypersensitivity to pyridoxine or any component of the formulation.
Warnings and precautions
Severe, permanent peripheral neuropathies reported. Neurotoxicity more common with long-term administration of large doses (>2 g/day). Some parenteral products contain aluminum (use caution in impaired renal function and neonates). High doses may be required to reverse neurological toxicity secondary to isoniazid toxicity. Doses >200 mg/day may cause dependence and withdrawal symptoms. Single vitamin deficiency is rare.