Ranitidine
- Atc Codes:A02BA02
- CAS Codes:66357-59-3
- PHARMGKB ID:66357-59-3
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Unlabeled Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Caution and personalized dose adjustment in patients with the following genotypes
- Other genes that may be involved
- Substrate of
- Inhibits
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Ranic, Raninorm, Ranitidin, Ulsal, Zantac; Belgium: Acidine, Docraniti, Gastran, Ranitidine, Ranitimed, Zantac; Bulgaria: Histac, Raniberl, Ranitidin, Ranitidine, Zantac; Cyprus: Arnetin, Brixoral, Epadoren, Lumaren, Raniplex, Ranitidine, Zantac; Czech Republic: Histac, Ranisan, Ranital, Ulcosan, Zantac; Denmark: Kuracid, Ranicodan, Ranitidin, Syrex, Zantac; Estonia: Arnetin, Raniberl, Ranisan, Zantac; Finland: Inside Brus, Ranimex, Ranisan, Ranitidin, Ranitidine, Ranixal, Zantac; France: Azantac, Raniplex, Ranitidine; Germany: Aciranit PB, Fluxidin PB, Junizac, Pyrosicur PB, Pyrosidin PB, Ran Lich, Raniberl, Ranibeta, Ranic, Ranicux, Ranidura T, Ranimon, Rani-Nerton, Raniprotect, Ranipyrosin PB, Ranitab, Ranitic, Ranitidin, Sostril, Zantic; Greece: Alphadine, Aova, B-Alcerin, Baroxal, Bindazac, Blumol, Brixoral, Epadoren, Ezopta, Gertocalm, Lomadryl, Lumaren, Narigen, Nipodur, Ptinolin, Ranitidine, Restopon, Rothonal, Semuele, Smaril, Synthomanet, Tupast, Verlost, Yara, Zantac, Zoliden, Zurfix; Hungary: Histac, Ranitic, Ranitidin, Ulceran-Teva, Umaren, Zantac; Ireland: Bellran, Gertac, Ranitic, Ranitidine, Ranopine, Zantac; Italy: Dolilux, Livin, Raniben, Ranibloc, Ranidil, Ranitidina, Sensigarg, Ulcex, Zantac; Latvia: Aciloc, Histac, Raniberl, Ranigast, Ranisan, Ranitidīns, Ultak, Zantac; Lithuania: Histac, Raniberl, Ranigast, Ranisan, Ranitan, Ranitidinas, Ulcosan, Zantac; Luxembourg: Docraniti, Ranitidine, Zantac; Malta: Arnetin, Asyran, Epadoren, Lumaren, Nipodur, Ranitidine, Zantac; Netherlands: Azantac, Ranitidine, Zantac; Poland: Gastranin, Histac, Novo-Ranidine, Ragastin, Raniberl, Ranic, Ranigast, Ranimax, Ranisan, Ranital, Ranitidinum, Ranitin, Ranitydyna, Riflux, Solvertyl, Zantac; Portugal: Bloculcer, Efective, Gastridina, Gastrolav, Gastrulcer, Pep-Rani, Peptab, Ranitidina, Ranitine, Stacer, Terposen, Zantac; Romania: Arnetin, Gertocalm, Histac, Ranital, Ranitidin, Ranitidina, Ulcoran, Zantac; Slovakia: Arnetin, Ranisal, Ranitan, Ulcosan, Zantac; Slovenia: Ranital; Spain: Alquen, Arcid, Ardoral, Coralen, Leiracid, Ranidin, Ranitidina, Terposen, Zantac; Sweden: Artonil, Inside Brus, Rani-Q, Ranitidin, Ranitidine, Zantac; UK: Ranitidine, Zantac.
North America
Canada: Acid Reducer, Nu-Ranit, Ranitidine, Zantac; USA: Zantac.
Latin America
Argentina: Acidex, Adesial, Alivian, Dualid, Espaven, Faboacid R, Gastrial, Gastrolets, Gastrosedol, Gastrozac, Labsidex, Lorbitidina, Luvier, Notrab, Prednocris, Ranimed, Ranitidina, Ranitral, Ranitul, Raticina, Reco, Reflux, Taural, Ulcotenk, Vingional, Vizerul, Zantac; Brazil: Antagon, Antak, Antidin, Aziliv, Label, Logat, Neosac, Ranidin, Ranidina, Ranidine, Ranitidina, Ranitil, Ranitin, Ranitinol, Ranition-Ranitidina, Ulceridina, Ulcerocin, Ulcoren, Zylium; Mexico: Acloral, Aldivina, Anistal, Avintac, Azanplus, Azantac, Bio-Gast, Credaxol, Dinaxin, Driges, Flatmed, Galidrin, Gastrec, Histac, Iqfadina, Katalem, Microtid, Midaven, Offentina, Phartidine, Radyn, Ranepal, Ranifarm, Ranifur, Raniger, Ranisen, Ranitidina, Raudil, Redacid, Sarcitec, Serranit, Serviradina, Sinhcloran, Syngasy, Terodul, Tianak, Ulcevit, Ulgastrin, Ulkodin, Ulmodhyl, Ulsaven, Ultran, Unitin.
Asia
Japan: Braulibera, Ceototac, Lanizac, Raden, Ranimerck, Ranitac, Ranitidine, Ranitizane, Tsurudek, Zamec, Zantac.
Drug combinations
Ranitidine and Domperidone
Ranitidine, Aluminum Hydroxide, Magnesium Hydroxide, and Simethicone
Chemistry
Ranitidine Hydrochloride: C~13~H~22~N~4~O~3~S HCl. Mw: 350.86. 1,1-Ethenediamine, N-[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N’-methyl-2-nitro-, monohydrochloride. CAS-66357-59-3.
Pharmacologic Category
Other Antihistamines. Antiulcer Agents and Acid Suppressants; Histamine H~2~-Antagonists. (ATC-Code: A02BA02).
Mechanism of action
Competitive inhibition of histamine at H~2~-receptors of gastric parietal cells, which inhibits gastric acid secretion, gastric volume, and hydrogen ion concentration.
Therapeutic use
Short-term and maintenance therapy of duodenal ulcer, gastric ulcer, gastroesophageal reflux, active benign ulcer, erosive esophagitis, and pathological hypersecretory conditions. As part of a multidrug regimen for H. pylori eradication.
Pregnancy and lactiation implications
Use with caution during pregnancy. Enters breast milk (use with caution in nursing women).
Unlabeled use
Recurrent postoperative ulcer, upper GI bleeding, prevention of acid-aspiration pneumonitis during surgery, and prevention of stress-induced ulcers.
Contraindications
Hypersensitivity to ranitidine or any component of the formulation.
Warnings and precautions
Long-term therapy may be associated with vitamin B~12~ deficiency. Reversible confusional states (rare), linked to use. Increased age (>50 years) and renal or hepatic impairment thought to be associated. Relief of symptoms does not preclude presence of gastric malignancy. Use with caution in hepatic impairment. Avoid use in history of acute porphyria (may precipitate attacks). Use with caution in renal impairment.