Rifapentine
- Atc Codes:J04AB05
- CAS Codes:61379-65-5
- PHARMGKB ID:61379-65-5
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Induces
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
North America
USA: Priftin.
Drug combinations
Chemistry
Rifapentine: C~47~H~64~N~4~O~12~. Mw: 877.03. Rifamycin, 3-[[(4-cyclopentyl-1-piperazinyl)imino]methyl]-. CAS-61379-65-5 (1985).
Pharmacologic Category
Antimycobacterials; Antituberculosis Agents. (ATC-Code: J04AB05).
Mechanism of action
Inhibits DNA-dependent RNA polymerase in susceptible strains of Mycobacterium tuberculosis (but not in mammalian cells). Bactericidal against both intracellular and extracellular MTB organisms.
Therapeutic use
Treatment of pulmonary tuberculosis. Must always be used in conjunction with at least one other antituberculosis drug to which the isolate is susceptible. It may also be necessary to add a third agent (either streptomycin or ethambutol) until susceptibility is known.
Pregnancy and lactiation implications
There are no adequate, well-controlled studies in pregnant women. Rifapentine should be used during pregnancy only if potential benefits justify potential risk to fetus. Contraindicated in nursing women.
Unlabeled use
Contraindications
Hypersensitivity to rifapentine, rifampin, rifabutin, any rifamycin analog, or any component of the formulation.
Warnings and precautions
Prolonged use may result in fungal or bacterial superinfection, including C. difficile-associated diarrhea and pseudomembranous colitis. Patients with abnormal liver tests and/or liver disease should only be given rifapentine when absolutely necessary. Use with caution in porphyria (exacerbation possible). Soft contact lenses should be removed during therapy (permanent staining may occur). Urine, feces, saliva, sweat, tears, skin, teeth, tongue, and CSF may be discolored to red/orange. MTB resistant to other rifamycins, including rifampin, likely to be resistant to rifapentine. Cross-resistance does not appear between rifapentine and other nonrifamycin antimycobacterial agents.