Rifaximin
- Atc Codes:A07AA11#D06AX11
- CAS Codes:80621-81-4
- PHARMGKB ID:80621-81-4
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Induces
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
Austria: Colidimin; Bulgaria: Normix; Czech Republic: Normix; Germany: Rifax, Rifaxan, Xifaxan; Greece: Lormyx, Rifacol; Hungary: Normix; Italy: Normix, Redactiv, Rifacol; Poland: Xifaxan; Portugal: Xifaxan; Romania: Normix; Slovakia: Normix; Spain: Spiraxin.
North America
USA: Xifaxan.
Latin America
Argentina: Coloximina, Rifadom; Mexico: Flonorm.
Drug combinations
Chemistry
Rifaximin: C~43~H~51~N~3~O~11~. Mw: 785.88. (1) 2,7-(Epoxypentadeca[1,11,13]trienimino)benzofuro[4,5-e]pyrido[1,2-a]benzimidazole-1,15(2H)-dione, 25-(acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-, – (2R*,16Z,18E,20R*,21R*,22S*,23S*,24S*,25R*,26S*,27R*,28E)]-; (2)(2S,16Z,18E,20S,21S,22R,23R,24R,25S,26S,27S,28E)-5,6,21,23,25 Pentahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)benzofuro[4,5-e]pyrido[1,2-a]benzimidazole-1,15(2H)-dione, 25-acetate. CAS-80621-81-4 (1992).
Pharmacologic Category
Miscellaneous Antibacterials; Rifamycins. (ATC-Code: A07AA11; D06AX11).
Mechanism of action
Rifaximin inhibits bacterial RNA synthesis by binding to bacterial DNA-dependent RNA polymerase.
Therapeutic use
Treatment of travelers’ diarrhea caused by noninvasive strains of E. coli.
Pregnancy and lactiation implications
Adverse events observed in animal reproduction studies. Due to limited oral absorption of rifaximin (<0.4%), exposure to fetus expected to be extremely low. Not recommended in nursing women.
Unlabeled use
Contraindications
Hypersensitivity to rifaximin, other rifamycin antibiotics, or any component of the formulation. Diarrhea with fever, or blood in stool.
Warnings and precautions
Prolonged use may result in fungal or bacterial superinfection, including C. difficile-associated diarrhea and pseudomembranous colitis. Efficacy not established for treatment of diarrhea due to pathogens other than E. coli, including C. jejuni, Shigella, and Salmonella.