Silver Sulfadiazine

Table of contents

  • Brand Names
  • Pharmacologic Category
  • Mechanism of Action
  • Therapeutic Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Genes that may be involved
  • Dosage
  • Pharmacokinetics and Pharmacodynamics
  • Special Considerations

Brand Names


Austria: Flammazine; Belgium: Sedoflame, Sulfasil, Flammazine; Bulgaria: Dermazin, Flammazine; Denmark: Flamazine, Flammazine; Estonia: Sulfargin; Finland: Flamazine; France: Flammazine; Germany: Brandiazin, Flammazine; Greece: Brandiazin, Flamazine, Flammazine, Sedoflame, Silver Sulfadiazine, Sylfio; Ireland: Flamazine; Italy: Bacternil, Sofargen; Latvia: Sulfargin; Lithuania: Sulfargin; Malta: Flamazine, Silvederma; Netherlands: Flammazine, Zilversulfadiazine; Poland: Dermazin; Portugal: Flammazine, Sicazine, Silvederma; Romania: Dermazin, Flammazine; Slovakia: Dermazin; Slovenia: Dermazin; Spain: Flammazine, Silvederma.

North America

Canada: Dermazin, Flamazine; USA: Silvadene, SSD, Thermazene.

Latin America

Argentina: Sulfatral; Brazil: Dermazine; Mexico: Argemol, Argentafil, Argental, Bioarginol-C, Hebermin, Sulfadiazina de Plata.

Drug combinations


Pharmacologic Category

Skin and Mucous Membrane Agents; Local Anti-infectives, Miscellaneous. Topical Antibiotic. (ATC-Code: D06BA01).

Mechanism of action

Acts upon bacterial cell wall and cell membrane. Bactericidal for many Gram-negative and Gram-positive bacteria and effective against yeast. Active against Pseudomonas aeruginosa, Pseudomonas maltophilia, Enterobacter species, Klebsiella species, Serratia species, Escherichia coli, Proteus mirabilis, Morganella morganii, Providencia rettgeri, Proteus vulgaris, Providencia species, Citrobacter species, Acinetobacter calcoaceticus, Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus species, Candida albicans, Corynebacterium diphtheriae, and Clostridium perfringens.

Therapeutic use

Prevention and treatment of infection in second- and third-degree burns.

Pregnancy and lactiation implications

As sulfonamides may cause kernicterus in neonates, silver sulfadiazine cream is contraindicated in pregnant women approaching or at term. Unknown whether topically applied silver sulfadiazine cream is distributed into milk.

Unlabeled use


Hypersensitivity to silver sulfadiazine or any component of the formulation. Premature infants or neonates <2 months of age (sulfonamides may displace bilirubin and cause kernicterus). Pregnancy (approaching or at term).

Warnings and precautions

Chemical similarities are present among sulfonamides, sulfonylureas, carbonic anhydrase inhibitors, thiazides, loop diuretics (except ethacrynic acid). Risk of cross-reaction exists in allergy to any of these compounds (avoid use when previous reaction severe). Prolonged use may result in fungal or bacterial superinfection, including C. difficile-associated diarrhea and pseudomembranous colitis. Systemic absorption may be significant and adverse reactions may occur. Use with caution in G6PD deficiency (hemolysis may occur), and in hepatic/renal impairment (sulfadiazine may accumulate). Use of analgesic might be needed before application.



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