Suramin
- Atc Codes:P01CX02
- CAS Codes:129-46-4#145-63-1
- PHARMGKB ID:129-46-4#145-63-1
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Unlabeled Use
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Dosage
- Pharmacokinetics and Pharmacodynamics
Brand Names
Europe
Germany: Germanin.
Drug combinations
Chemistry
Suramin sodium: C~51~H~34~N~6~Na~6~O~23~S~6~. Mw: 1429.17. (1) 1,3,5-Naphtalenetrisulfonic acid, 8,8′-[carbonylbis[imino-3,1-phenylene)carbonylimino]]bis-,hexasodium salt; (2) Hexasodium 8,8′-[ureylenebis[m-pheylenecarbonylimino(4-methyl-m-phenylene)carbonylimino]]di-1,3,5-naphtalenetrisulfonate. CAS-129-46-4; CAS-145-63-1 (suramin).
Pharmacologic Category
Miscellanous Antiprotozoals. (ATC-Code: P01CX02).
Mechanism of action
Suramin inhibits a number of growth factors and enzymes essential to cell proliferation such as platelet-derived growth factor, fibroblast growth factor, DNA polymerase, glycerol phosphate oxidase, reverse transcriptase, and various lysosomal enzymes. Suramin may also have some angiogenic inhibitory activity.
Therapeutic use
Treatment of early human African trypanosomiasis (sleeping sickness; trypanosome fever), without CNS involvement. As a secondary agent in the treatment of onchocerciasis (river blindness).
Pregnancy and lactiation implications
Unlabeled use
Prostate cancer. Chemosensitizing agent in treatment of various solid tumors.
Contraindications
Hypersensitivity to suramin or any component of the formulation.
Warnings and precautions
Use with caution in significant hepatic impairment, in decreased serum albumin levels, and in malnourished patients.