May cause CNS depression. Erythema multiforme and Steven’s-Johnson syndrome reported (including fatalities). Ophthalmic changes may occur and persist >1 year. Use with caution in anemia. Not suitable treatment for mixed infections with Ascaris. Use with caution in dehydration, in hepatic impairment (jaundice, cholestasis, parenchymal liver damage occurred), in malnutrition, and in renal impairment. Safety and efficacy limited in children <14 kg (30 lb).