Tioconazole
- Atc Codes:D01AC07#G01AF08
- CAS Codes:65899-73-2
- PHARMGKB ID:65899-73-2
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Inhibits
- Dosage
- Pharmacokinetics and Pharmacodynamics
Brand Names
Europe
Finland: Gyno-Trosyd; France: Gyno Trosyd; Greece: Cotinazin; Poland: Gyno-Trosyd; Portugal: Gino-Trosyd.
North America
USA: Tioconazole, Vagistat-1.
Latin America
Argentina: Honguil, Niofen; Brazil: Gino Conazol.
Drug combinations
Tioconazol and Hydrocortisone
Tioconazol and Undecylenic Acid
Chemistry
Tioconazole: C~16~H~13~Cl~3~N~2~OS. Mw: 387.71. (1) 1H-Imidazole, 1-[2-[(2-chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-; (2) 1-[2,4-Dichloro-[β-(2-chloro-3-thenyl)oxy]phenethyl]imidazole. CAS-65899-73-2 (1978).
Pharmacologic Category
Skin and Mucous Membrane Agents; Antifungals; Azoles. Vaginal Antifungal Agent. (ATC-Code: D01AC07; G01AF08).
Mechanism of action
A 1-substituted imidazole derivative with broad antifungal spectrum against a wide variety of dermatophytes and yeasts, including Trichophyton mentagrophytes, T. rubrum, T. erinacei, T. tonsurans, Microsporum canis, Microsporum gypseum, and Candida albicans.
Therapeutic use
Local treatment of vulvovaginal candidiasis.
Pregnancy and lactiation implications
Use with caution in pregnancy. Excretion in breast milk unknown (not recommended in nursing women).
Unlabeled use
Contraindications
Hypersensitivity to tioconazole or any component of the formulation.
Warnings and precautions
Irritation or sensitization can occur. Petrolatum-based vaginal products may damage rubber or latex condoms or diaphragms.