Tolnaftate
- Atc Codes:D01AE18
- CAS Codes:2398-96-1
- PHARMGKB ID:2398-96-1
Table of contents
- Brand Names
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Drug Interactions
- Dosage
Brand Names
Europe
France: Sporiline; Germany: Tinatox, Tonoftal; Hungary: Chinofungin, Digifungin; Ireland: Mycil Athlete’s Foot, Tinaderm; Luxembourg: Sorgoa; Malta: Scholl Athlete’s Foot; Portugal: Tinaderme, Tolnaftato; UK: Scholl Athlete’s Foot.
North America
Canada: Absorbine Jr Antifungal Liquid, Avon Foot Works Therapeutic Antifungal Foot Cream, Dr. Scholl’s Athlete’s Foot Powder, Flexitol Medicated Foot Cream, Fungicure, Odor-Eaters Foot & Sneaker Spray, Pitrex, Proclearz Antifungal, Tinactin, Tolnaftate Antifungal, Zeasorb; USA: Blis-To-Sol, Fungi-Guard, Gold Bond Antifungal, Mycocide NS, Podactin, Q-Naftate, Tinactin Antifungal, Tinaderm, Ting Cream.
Latin America
Mexico: Excelsior Mic, Tinoxal, Tolnaftato.
Asia
Japan: Hi-Alarzin, Separin.
Drug combinations
Tolnaftate and Chlorhexidine Gluconate
Tolnaftate, Betamethasone, Gentamicin, and Nystatin
Chemistry
Tolnaftate: C~19~H~17~NOS. Mw: 307.41. (1) Carbamothioic acid, methyl(3-methylphenyl)-, O-2-naphthalenyl ester; (2) O-2-Naphthyl m,N-dimethylthiocarbanilate. CAS-2398-96-1 (1963).
Pharmacologic Category
Skin and Mucous Membrane Agents; Antifungals; Thiocarbamates. Topical Antifungal Agent. (ATC-Code: D01AE18).
Mechanism of action
Distorts hyphae and stunts mycelial growth in susceptible fungi.
Therapeutic use
Treatment of tinea pedis, tinea cruris, tinea corporis.
Pregnancy and lactiation implications
Unlabeled use
Contraindications
Hypersensitivity to tolnaftate or any component of the formulation. Nail and scalp infections.
Warnings and precautions
Discontinue if sensitivity or irritation occurs. Not for self-medication in children <2 years of age. For topical use only.