Traveler’s Diarrhea and Cholera Vaccine

Table of contents

  • Brand Names
  • Pharmacologic Category
  • Therapeutic Use
  • Pregnancy and Lactation Implications
  • Contraindications
  • Warnings and Precautions
  • Adverse Reactions
  • Drug Interactions
  • Nutrition/Nutraceutical Interactions
  • Dosage

Brand Names


Austria: Dukoral; Belgium: Dukoral; Bulgaria: Dukoral; Cyprus: Dukoral; Denmark: Dukoral; Estonia: Dukoral; Finland: Dukoral; France: Dukoral; Germany: Dukoral; Hungary: Dukoral; Ireland: Dukoral; Italy: Dukoral; Latvia: Dukoral; Lithuania: Dukoral; Luxembourg: Dukoral; Malta: Dukoral; Netherlands: Dukoral; Poland: Dukoral; Portugal: Dukoral; Romania: Dukoral; Slovakia: Dukoral; Slovenia: Dukoral; Spain: Dukoral; Sweden: Dukoral; UK: Dukoral.

North America

Canada: Dukoral.

Latin America

Argentina: Orochol; Brazil: Vacina Oral Contra Cólera.


Japan: Dukoral.

Drug combinations


Pharmacologic Category

Serums, Toxoids, and Vaccines; Vaccines. (ATC-Code: J07A).

Mechanism of action

Therapeutic use

Protection against traveler’s diarrhea and/or cholera in adults and children ≥2 years of age caused by enterotoxigenic E. coli or cholera caused by V. cholerae O1 (classical and El Tor biotypes).

Pregnancy and lactiation implications

Vaccine not recommended for use during pregnancy. Use should only be considered if potential benefit to mother outweighs potential risk to fetus. Excretion in breast milk unknown.

Unlabeled use


Hypersensitivity to any component of the formulation. Acute illness (excluding minor illnesses such as mild upper respiratory tract infection).

Warnings and precautions

Anaphylactoid and/or hypersensitivity reactions might occur during vaccine use. May not protect 100% of susceptible individuals; has not been shown to protect against cholera caused by 0139 Bengal strain in South Asia. Use with caution in severely immunocompromised patients (e.g. patients receiving chemo/radiation therapy or other immunosuppressive therapy (including high-dose corticosteroids)); may have reduced response to vaccination. For oral use only (should not be administered I.M., I.V., or SubQ).



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