Triprolidine
- Atc Codes:R06AX07
- CAS Codes:6138-79-0#550-70-9#486-12-4
- PHARMGKB ID:6138-79-0#550-70-9#486-12-4
Table of contents
- Drug Combinations
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Inhibits
- Drug Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Drug combinations
Triprolidine and Dextromethorphan
Triprolidine and Pseudoephedrine
Triprolidine, Acetaminophen, and Pseudoephedrine
Triprolidine, Codeine, and Pseudoephedrine
Triprolidine, Dextromethorphan, and Pseudoephedrine
Triprolidine, Guaifenesin, and Pseudoephedrine
Chemistry
Triprolidine Hydrochloride: C~19~H~22~N~2~ HCl H~2~O. Mw: 332.87. (1) Pyridine, 2-[1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]-, monohydrochloride, monohydrate, (E)-; (2)(E)-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine monohydrochloride monohydrate. CAS-6138-79-0; CAS-550-70-9 (anhydrous); CAS-486-12-4 (triprolidine).
Pharmacologic Category
First Generation Antihistamines; Histamine H~1~ Antagonist. (ATC-Code: R06AX07).
Mechanism of action
Blocks H~1~-receptor sites, thereby preventing action of histamine on cell. Suppresses flare and pruritus that accompany endogenous release of histamine. Has anticholinergic and sedative effects.
Therapeutic use
Symptomatic relief of seasonal (e.g. hay fever) or perennial (nonseasonal) allergic rhinitis or nonallergic (vasomotor) rhinitis. Symptomatic relief of allergic conjunctivitis caused by foods or inhaled allergens. Symptomatic treatment of mild, uncomplicated allergic skin manifestations of urticaria and angioedema. Used in fixed combination with other agents (e.g. pseudoephedrine) for symptomatic relief of rhinorrhea, sneezing, oronasopharyngeal itching, lacrimation, itching eyes, and/or other symptoms (e.g. sinus congestion) associated with seasonal or perennial allergic rhinitis or nonallergic rhinitis. Used in fixed combination with other agents (e.g. pseudoephedrine) for self-medication for symptomatic relief of sinus congestion and other symptoms associated with common cold.
Pregnancy and lactiation implications
Should be used with caution in pregnant women. Distributed into milk.
Unlabeled use
Contraindications
Use contraindicated in neonates and premature infants. Breast-feeding women. Patients receiving MAOI therapy. Asthmatic attacks. Known hypersensitivity to triprolidine or any ingredient in the formulation.
Warnings and precautions
Due to its anticholinergic effects, use with extreme caution in angle-closure glaucoma, pyloroduodenal obstruction, bladder-neck obstruction, and symptomatic prostatic hypertrophy. Use with extreme caution in history of bronchial asthma, increased IOP, hyperthyroidism, or cardiovascular disease (e.g. hypertension). Risk of drowsiness. Possible excitability (especially in children). Use not recommended in premature or full-term neonates. Possible paradoxical excitement (e.g. restlessness, insomnia, tremors, euphoria, nervousness, delirium, palpitation, seizures), especially in children. Use in children <4 months of age not recommended. Children <6 years of age should receive triprolidine only under direction of a clinician.