Vasopressin
- Atc Codes:H01BA01
- CAS Codes:113-79-1#50-57-7
- PHARMGKB ID:113-79-1#50-57-7
Table of contents
- Brand Names
- Chemistry
- Pharmacologic Category
- Mechanism of Action
- Therapeutic Use
- Unlabeled Use
- Pregnancy and Lactation Implications
- Contraindications
- Warnings and Precautions
- Adverse Reactions
- Genes that may be involved
- Drug Interactions
- Nutrition/Nutraceutical Interactions
- Dosage
- Pharmacokinetics and Pharmacodynamics
- Special Considerations
Brand Names
Europe
UK: Pitressin.
North America
Canada: Pressyn, Vasopressin.
Asia
Japan: Pitressin.
Drug combinations
Chemistry
Vasopressin: C~46~H~65~N~15~O~12~S~2~. Mw: 1084.23 (Arg form); C~46~H~65~N~13~O~12~S~2~. Mw: 1056.22 (Lys form). (1) Vasopressin, 8-L-arginine-; (2) Vasopressin, 8-L-lysine-. CAS-113-79-1 (Arg form); CAS-50-57-7 (Lys form).
Pharmacologic Category
Hormones and Synthetic Substitutes; Pituitary. Antidiuretic Hormone Analog. (ATC-Code: H01BA01).
Mechanism of action
Increases cyclic adenosine monophosphate which increases water permeability at renal tubule resulting in decreased urine volume and increased osmolality. Causes peristalsis by directly stimulating smooth muscle in GI tract. Direct vasoconstrictor without inotropic or chronotropic effects.
Therapeutic use
Treatment of diabetes insipidus. Differential diagnosis of diabetes insipidus.
Pregnancy and lactiation implications
Animal reproduction studies not conducted. Vasopressin and desmopressin used safely during pregnancy and nursing.
Unlabeled use
Adjunct in treatment of GI hemorrhage and esophageal varices. Pulseless arrest (ventricular tachycardia/ventricular fibrillation, asystole/pulseless electrical activity). Vasodilatory shock (septic shock).
Contraindications
Hypersensitivity to vasopressin or any component of the formulation.
Warnings and precautions
I.V. infiltration may lead to severe vasoconstriction and localized tissue necrosis, also gangrene of extremities, tongue, and ischemic colitis. May cause water intoxication. Use with caution in asthma, and in cardiovascular disease, including arteriosclerosis. Use with caution in goiter with cardiac complications, in history of migraines, and in renal disease, including chronic nephritis with nitrogen retention. Use with caution in history of seizure disorder, and in vascular disease. Caution in the elderly (have decreased responsiveness to vasopressin with respect to its effects on water homeostasis).